| Dosage | : | Tablet |
| Contains | : | Atenolol |
| Category | : | Beta-Blockers (Antihypertensives) |
| Uses | : | Hypertension, Chronic stable angina |
| Price | : |
Aten contains Atenolol. Atenolol is a cardioselective beta blocker. Used in the treatment of cardiovascular diseases.
Aten Tablet is used to treat hypertension (high blood pressure). This is a combination of two medicines that controls blood pressure when a single medication is not effective. It helps to lower high blood pressure and thus reduces the chances of future heart attack and stroke.
Aten is product from Cadila Healthcare Ltd (Zydus Cadila). Zydus Cadila is an Indian pharmaceutical company headquartered in Ahmedabad, Gujarat, India. The company is one of the leading pharmaceutical companies in India. It is a manufacturer of generic drugs.
High blood pressure
High BP is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
There are two types of high blood pressure.
Primary (essential) hypertension
For most adults, there’s no identifiable cause of high blood pressure. This type of high blood pressure, called primary (essential) hypertension, tends to develop gradually over many years.
Secondary hypertension
Some people have high blood pressure caused by an underlying condition. This type of high blood pressure, called secondary hypertension, tends to appear suddenly and cause higher blood pressure than does primary hypertension. Various conditions and medications can lead to secondary hypertension, including:
- Obstructive sleep apnea
- Kidney problems
- Adrenal gland tumors
Uncontrolled high blood pressure can lead to complications including:
- Heart attack or stroke: High blood pressure can cause hardening and thickening of the arteries (atherosclerosis), which can lead to a heart attack, stroke or other complications.
- Aneurysm: Increased blood pressure can cause your blood vessels to weaken and bulge, forming an aneurysm. If an aneurysm ruptures, it can be life-threatening.
- Heart failure: To pump blood against the higher pressure in your vessels, the heart has to work harder. This causes the walls of the heart’s pumping chamber to thicken (left ventricular hypertrophy). Eventually, the thickened muscle may have a hard time pumping enough blood to meet your body’s needs, which can lead to heart failure.
Also, in some cases, it can lead to vision loss, difficulty in memory and understanding.
Angina pectoris
Angina pectoris is the medical term for chest pain or discomfort due to coronary heart disease. It occurs when the heart muscle doesn’t get as much blood as it needs. This usually happens because one or more of the heart’s arteries is narrowed or blocked, also called ischemia.
Angina usually causes uncomfortable pressure, fullness, squeezing or pain in the center of the chest.
The pain or discomfort occurs when the heart must work harder, usually during physical exertion. Doesn’t come as a surprise, and episodes of pain tend to be alike. It usually lasts a short time (5 minutes or less)
Dosage
As directed by your Physician
Administration
As directed by your Physician
Adverse Reactions/ Side Effects
Blood and lymphatic system disorders: Thrombocytopenia. Cardiac disorders: Bradycardia. Eye disorders: Dry eyes, visual disturbances. Gastrointestinal disorders: Nausea, diarrhoea, dry mouth. General disorders and administration site conditions: Fatigue. Musculoskeletal and connective tissue disorders: Lupus-like syndrome. Nervous system disorders: Dizziness, headache. Psychiatric disorders: Hallucinations, depression, nightmare, psychoses. Reproductive system and breast disorders: Impotence. Skin and subcutaneous tissue disorders: Psoriasiform skin reactions, purpura, alopecia. Vascular disorders: Postural hypotension, cold extremities, Raynaud’s phenomenon.
Warnings and Precautions
Patients with bronchospasm or reversible obstructive airways disease, diabetes mellitus, peripheral vascular disease, Raynaud’s disease, Prinzmetal’s angina, myasthenia gravis, psoriasis and thyroid diseases. Avoid abrupt withdrawal. Renal impairment. Elderly. Pregnancy and lactation. Monitoring Parameters Monitor blood pressure, heart rate, ECG, and serum glucose (in patients with diabetes mellitus).
Contraindications
Patients with bradycardia, cardiogenic shock, hypotension, metabolic acidosis, 2nd or 3rd degree heart block, severe peripheral arterial disease, sick sinus syndrome (without pacemaker), uncompensated cardiac failure and untreated phaeochromocytoma.
Drug Interactions
Additive effects with Ca channel blockers (e.g. verapamil, diltiazem) and catecholamine-depleting agents (e.g. reserpine). May increase atrioventricular conduction time with digitalis glycosides. May aggravate rebound hypertension following clonidine withdrawal. Class I anti-arrhythmic drugs (e.g. disopyramide) and amiodarone may potentiate effects on atrial-conduction time and induce negative inotropic effect. May increases hypoglycaemic effects of insulin and oral antidiabetic drugs. Decreased hypotensive effects with concomitant use of NSAIDs (e.g. ibuprofen, indometacin). May increases risk of hypotension and attenuates reflex tachycardia with anaesthetic drugs.
Overdosage
Symptoms: Bradycardia, hypotension, bronchospasm, and acute cardiac failure; hypoglycaemia, impaired conduction, decreased cardiac contractility, heart block, shock, and cardiac arrest may also occur. Management: Initiate symptomatic and supportive treatment. Gastric lavage or activated charcoal may be used in acute atenolol overdose. IV atropine sulfate may be given for bradycardia and IV isoproterenol HCl for 2nd or 3rd degree AV block, a transvenous cardiac pacemaker may also be used. For severe hypotension, a vasopressor (e.g. dobutamine, norepinephrine) may be given and for bronchospasm, a β2-adrenergic agonist (e.g. isoproterenol, terbutaline). IV glucagon may also be useful if hypotension is refractory to vasopressors and IV glucose is used for hypoglycaemia. A cardiac glycoside, diuretic and oxygen should be used for cardiac failure. In severe cases, haemodialysis may be useful in enhancing elimination.
Storage
Intravenous: Store below 25°C. Oral: Store below 25°C.
Mechanism of Action
Atenolol belongs to a class of drugs known as beta-blockers. It works by blocking the action of certain natural chemicals in your body, such as epinephrine, on the heart and blood vessels. This effect lowers the heart rate, blood pressure, and strain on the heart.