National Health Service (NHS), UK, endorses the use of Actrapid in Diabetes patients.
Actrapid Injection is used in the treatment of diabetes mellitus. Diabetes mellitus is a disorder in which the body either does not produce enough insulin to control the blood glucose or when the body does not respond to the produced insulin effectively.
Insulin is a natural substance produced by the pancreas which helps in utilizing glucose for energy production. Patients with diabetes mellitus may not be able to utilize glucose due to the insufficient production of insulin or due to the body’s inability to use insulin or both. It helps in the utilization of glucose and controlling blood glucose levels. Actrapid is replacement insulin which is very similar to the insulin made by the pancreas. Insulin can be given to diabetes patients.
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Your doctor may have prescribed Actrapid because you could be suffering from Diabetes.
Actrapid is an injectable medication that contains the active substance Regular Human Insulin to control high blood sugar. This could be type-1 diabetes which arises when the pancreas is unable to produce insulin and type-2 diabetes which arises when the body is not able to use insulin effectively.
Diabetes occurs when your blood glucose (blood sugar) is too high.
Blood glucose is your main source of energy and it comes from the food you consume. Your pancreas produces a hormone called insulin, which helps convert the glucose from your food to energy by carrying it into your cells.
In a diabetic patient, their body doesn’t produce enough insulin or doesn’t manage insulin well. Glucose then accumulates in your blood and doesn’t reach your cells causing a host of health problems and diseases that may include:
Actrapid has been known to work well among patients with impaired insulin production, which in turn leads to diabetes.
Pregnancy (insulin requirements tend to fall during the 1st trimester, increase during the 2nd and 3rd) and lactation. Regular monitoring of HbA1c and blood glucose concentrations.
Possible absence of hypoglycaemic warning symptoms with β-blockers. Decreased hypoglycaemic effect with corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, phenothiazine derivatives, somatropin, sympathomimetic agents, thyroid hormones, oestrogens, progestins (e.g. in oral contraceptives), protease inhibitors and atypical antipsychotic (e.g. olanzapine and clozapine). Increased hypoglycaemic effect with oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates and sulfonamide antibiotics. Decreased insulin resistance with octreotide and lanreotide. Increased risk of wt gain and peripheral oedema with pioglitazone, rosiglitazone. Decreased effect of sermorelin.
Symptoms: Hypoglycaemia. Management: In mild hypoglycaemic episodes, treat with oral glucose. In severe hypoglycaemic episodes, where the patient has become unconscious, treat with IM/SC glucagon (0.5-1 mg) or IV glucose. If the patient does not respond to glucagon within 10-15 minutes, IV glucose must be given. Once consciousness is regained, admin oral carbohydrates to prevent a relapse.
Mechanism of Action
Insulin lowers blood glucose levels. It regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal.