Amaryl 2 MG Tablet is a long-acting oral anti-diabetic which lowers the blood sugar level. It is used only in patients diagnosed with Type II Diabetes. It may be used along with Insulin or other medicines in order to achieve better control over the blood sugar levels. Amaryl contains Glimepiride. Glimepiride is a medium-to-long acting sulfonylurea anti-diabetic drug. Glimepiride is the first third-generation sulfonylurea, and is very potent.
Glimepiride stimulates the insulin release from functioning pancreatic β-cells and inhibits gluconeogenesis at hepatic cells. It also increases insulin sensitivity at peripheral target sites.
Amaryl is product from Sanofi. Sanofi is a French multinational pharmaceutical company headquartered in Paris, France, as of 2013.
Sanofi engages in the research and development, manufacturing and marketing of pharmaceutical drugs principally in the prescription market, but the firm also develops over-the-counter medication. The company covers seven major therapeutic areas: cardiovascular, central nervous system, diabetes, internal medicine, oncology, thrombosis and vaccines (it is the world’s largest producer of the latter through its subsidiary Sanofi Pasteur).
Diabetes type 2
Insulin is a hormone made by your pancreas that acts like a key to let blood sugar into the cells in your body for use as energy. If you have type-2 diabetes, cells don’t respond normally to insulin; this is called insulin resistance. Your pancreas makes more insulin to try to get cells to respond. Eventually your pancreas can’t keep up, and your blood sugar rises, setting the stage for prediabetes and type-2 diabetes. High blood sugar is damaging to the body and can cause other serious health problems, such as heart disease, vision loss, and kidney disease.
People are at risk for developing type-2 diabetes if they have prediabetes, are overweight, are 45 years or older, have a parent, brother, or sister with type-2 diabetes, are less physically active or had gestational diabetes (diabetes during pregnancy). It can be prevented or delayed with simple, proven lifestyle changes such as losing weight if you’re overweight, eating healthier, and getting regular physical activity.
As directed by your Physician
As directed by your Physician
Adverse Reactions/ Side Effects
Vomiting, GI pain, diarrhoea; pruritus, erythema, urticaria, morbilliform, maculopapular eruptions; leukopenia, agranulocytosis, thrombocytopenia, haemolytic anaemia, aplastic anaemia and pancytopenia; hyponatraemia; changes in accommodation, blurred vision, jaundice.
Warnings and Precautions
Monitor fasting blood glucose to determine therapeutic response, monitor glycosylated hemoglobin every 3 to 6 months
Increased risk of CV mortality. Elderly; hepatic and renal impairment. Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) in patients with CHF or hepatic cirrhosis. Monitor blood-glucose concentration. Pregnancy, lactation.
Diabetic ketoacidosis with or without coma.
Caution when used during pregnancy Category C: Drugs should be given only if the potential benefit justifies the potential risk to the foetus. Caution when used during lactation
In Geriatric – Increased risk for development of hypoglycemia. Hypoglycemia may be difficult to detect in elderly patients.
NSAIDs, salicylates, sulphonamides, chloramphenicol, coumarin, probenecid, CYP2C9 inhibitors, fibric acid derivatives, pegvisomant, TCAs, MAOIs and β-adrenergic blockers may potentiate the hypoglycaemic action of glimepiride. Thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, oestrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, rifampicin, CYP2C9 inducers and isoniazid may reduce hypoglycaemic effect of glimepiride. May increase the serum levels of ciclosporin. Serum levels may be increased by fluconazole.
A glimepiride overdose can cause life-threatening hypoglycemia. Symptoms of severe hypoglycemia include extreme weakness, confusion, tremors, sweating, fast heart rate, trouble speaking, nausea, vomiting, rapid breathing, fainting, and seizure (convulsions)
Mechanism of Action
Glimepiride acts as an insulin secretagogue. It lowers blood sugar by stimulating the release of insulin by pancreatic beta cells and by inducing increased activity of intracellular insulin receptors.