Inflammatory skin disorders, including pemphigus vulgaris
Minimal change nephrotic syndrome
Acute interstitial nephritis
Haemolytic anaemia (autoimmune)
Acute and lymphoblastic and chronic lymphocytic leukaemia
Idiopathic thrombocytopenic purpura
Immunosuppression in transplantation
Betnesol is a brand from GlaxoSmithkline, which is the world’s leading research based pharmaceutical, healthcare and vaccine company. Through its accomplished and dedicated workforce, GSK applies its expertise to innovate various medicines that contributes to the health and well-being of the people of all generations around the world. The company is committed to improve the quality of human life by enabling people to do more, feel better and live longer.
Some types of allergies, including allergies to foods and insect stings, can trigger a severe reaction known as anaphylaxis. A life-threatening medical emergency, anaphylaxis can cause you to go into shock. Signs and symptoms of anaphylaxis include:
Loss of consciousness
A drop in blood pressure
Severe shortness of breath
A rapid, weak pulse
Nausea and vomiting
As directed by your Physician
As directed by your Physician
Adverse Reactions/ Side Effects
Suppression of HPA axis, growth suppression especially in children, menstrual irregularity and amenorrhoea, Cushingoid facies, hirsutism, weight gain, impaired carbohydrate tolerance, increased appetite, hyperhidrosis; recurrence of dormant TB, opportunistic infections; osteoporosis, vertebral and long bone fractures, avascular osteonecrosis, tendon rupture, proximal myopathy; Na and water retention, HTN, K loss, hypokalaemic alkalosis; affective disorder (e.g. irritable, euphoric, depressed and labile mood, suicidal thoughts), psychotic reactions ( e.g. mania, delusions, hallucinations and aggravation of schizophrenia), behavioural disturbances.
Patient w/ history of severe affective disorder esp steroid psychosis, osteoporosis, CHF or HTN, recent MI, DM, history of TB, glaucoma, corticosteroid-induced myopathy, epilepsy, peptic ulceration, hypothyroidism, myasthenia gravis; psoriasis (topical). Renal and hepatic impairment. Children. Pregnancy and lactation. Patient Counselling Avoid abrupt withdrawal. Avoid exposure to chickenpox or measles. Monitoring Parameters for hypothalamic-pituitary-adrenal (HPA) axis suppression, especially in children.
Untreated infections (systemic and topical). Idiopathic thrombocytopenic purpura (IM).
Increased plasma concentration when used w/ CYP3A4 inhibitors (e.g. ritonavir, itraconazole), and OCs. Decreased therapeutic effect when concurrently used w/ rifampicin, rifabutin, carbamazepine, phenobarbitone, phenytoin, primidone, aminoglutethimide and ephedrine. May antagonise the effect of hypoglycaemic agents, antihypertensives, neuromuscular blockers (e.g. vecuronium), and diuretics. Increased risk of hypokalaemia w/ acetazolamide, loop/thiazide diuretics, carbenoxolone, theophylline, cardiac glycosides.
May inhibit the growth promoting effects of somatropin. Increased risk of tendon rupture w/ concurrent use of fluoroquinolones. May increase the metabolism of quetiapine and tretinoin. Increased risk of GI bleeding when used w/ NSAIDs. May enhance the efficacy of coumarin anticoagulants.
Intramuscular: Store between 15-30°C. Nasal: Store between 15-30°C. Ophthalmic: Store between 15-30°C. Oral: Store between 15-30°C. Otic/Aural: Store between 15-30°C. Parenteral: Store between 15-30°C. Topical/Cutaneous: Store between 15-30°C.
Mechanism of Action
Betamethasone is a corticosteroid w/ mainly glucocorticoid activity. It induces phospholipase A2inhibitory lipase (lipocortins) and sequentially inhibits the release of arachidonic acid, thereby depressing the formation, release, and activity of prostaglandins, leukotrienes, and other inflammatory mediators.