CCM contains Calcium Citrate + Vitamin D3. This combination medication is used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany).
It may also be used in certain patients to make sure they are getting enough calcium (e.g., women who are pregnant, nursing, or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).
Calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Vitamin D helps your body absorb calcium and phosphorus. Having the right amounts of vitamin D, calcium, and phosphorus is important for building and keeping strong bones.
CCM is product of GlaxoSmithKline plc. GSK is a British multinational pharmaceutical company headquartered in Brentford, London. Established in 2000, by a merger of Glaxo Wellcome and SmithKline Beecham, GSK was the world’s sixth largest pharmaceutical company according to Forbes as of 2019.
Osteoporosis is a condition that affects the bones. Its name comes from Latin for “porous bones.”
The inside of a healthy bone has small spaces, like a honeycomb. Osteoporosis increases the size of these spaces, causing the bone to lose strength and density. In addition, the outside of the bone grows weaker and thinner.
Osteoporosis can occur in people of any age, but it’s more common in older adults, especially women. People with osteoporosis are at a high risk of fractures, or bone breaks, while doing routine activities such as standing or walking. The most commonly affected bones are the ribs, hips, and the bones in the wrists and spine.
Hypoparathyroidism is a rare condition that occurs when the parathyroid glands in the neck don’t produce enough parathyroid hormone (PTH).
The major function of PTH is to regulate the level of calcium in your body. It also controls the level of phosphorus and has a role in the production of the active form of vitamin D. All of these activities are required to maintain calcium balance.
Having too little PTH causes low levels of calcium and high levels of phosphorus in the body. This condition may not cause any serious medical problems when it’s caught early, but it does require lifelong monitoring and treatment.
Impaired calcium absorption in achlorhydria which is common in elderly. Increased risk of hypercalcaemia and hypercalciuria in hypoparathyroid patients on high doses of vitamin D. History of kidney stones. Renal impairment.
Patients with hypercalcaemia, hypercalciuria or hypophosphatemia. Nephrolithiasis, hypervitaminosis D.
Reduced absorption of tetracyclines, quinolones and oral biphosphates with concurrent calcium use. Calcium absorption may be reduced by corticosteriods. Increased risk of hypercalcemia and metabolic alkalosis with thiazide diuretics. High blood calcium level may increase the effect of cardiac glycosides. Reduced erlotinib efficacy with calcium. Increased risk of hypercalaemia with paricalcitol. Enzyme-inducing antiepileptics increases the metabolism of Vit D.
Potentially Fatal: Fatal encephalopathy can occur in patients with renal failure when given calcium citrate and aluminium products concurrently due to marked rise in aluminium levels.
Food Interactions: Foods that are rich in oxalic acid (e.g. spinach and rhubarb) and phytic acid (e.g. whole cereals) may reduce calcium absorption by formation of insoluble calcium salts.
Overdose can lead to hypercalcaemia. Symptoms: Anorexia, thirst, nausea, vomiting, abdominal pain, muscle weakness, mental disturbances, polydipsia, polyuria and cardiac arrhythmias. Treatment of hypercalcaemia: Rehydrate and discontinue calcium supplement and any treatment with thiazide diuretics or vitamin D. Corticosteriods may be given to reduce the GI absorption of calcium. Biphosphonates may also be used for life-threatening hypercalcaemia.
Mechanism of Action
Calcium salt can be used in the prevention and treatment of calcium deficiency states. It is also used as an adjunct in the prevention and treatment of osteoporosis. Vitamin D3 is a fat-soluble sterol. It is necessary for the regulation and regulation of calcium and phosphate homoeostasis and bone mineralisation.