CILACAR

Dosage : Tablet
Contains : Cilnidipine
Category : Calcium antagonist
Uses : Hypertension
Price :

Cilnidipine is an antihypertensive drug. It comes in a form of film-coated tablet and is available in three strengths, 5 mg, 10 mg and 20 mg.

 

It acts on the calcium channels of blood vessels and blocks the incoming calcium. This helps in suppressing the contraction of blood vessels, thereby reducing blood pressure. Cilnidipine dilates both arterioles and venules thus reducing the pressure.

 

The additional benefit of Cilacar is that it decreases blood pressure safely and effectively without excessive blood pressure reduction or tachycardia (an abnormally rapid heart rate).

 

It can also be used in elderly patients with diabetes and compromised renal function with chronic kidney disease.

 

Cilnidipine is launched in India by JB Chemicals & Pharmaceuticals Ltd. (JBCPL) in 2007. Established in 1976, JBCPL is one of India’s fastest growing pharmaceutical companies. It is an integrated, research-oriented organisation with a focus on supplying affordable, quality products both in India and International markets. JBCPL is trusted by healthcare professionals globally and operates in more than 30 countries across the world.

Cilacar is an orally available medication that contains Cilnidipine. It blocks the influx of calcium inside the blood vessels. This helps in relaxation and dilation of blood vessels thus reducing the blood pressure.

 

Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. High blood pressure is a major risk factor for coronary heart disease and a cause of heart attacks. A build-up of cholesterol is part of the process that narrows arteries, called atherosclerosis, in which plaques form and cause restriction of blood flow leading to high blood pressure.

 

In a hypertension patient, blood pressure is the force exerted by the blood against the walls of the blood vessels. Cilacar can be used to treat hypertension, which if unattended can cause a host of health problems and diseases that may include:

  • Hypertriglyceridemia
  • Cardiovascular diseases
  • Stroke

 

Cilacar has been proven to work well among patients with high blood pressure.

Dosage

As prescribed by your Physician

Administration

As prescribed by your Physician

Adverse Reactions/ Side Effects

Dizziness; flushing; headache; hypotension; peripheral oedema; tachycardia; palpitations; GI disturbances; increased micturition frequency; lethargy; eye pain; depression; ischaemic chest pain; cerebral or myocardial ischaemia; transient blindness; rashes; fever; abnormal liver function; gingival hyperplasia; myalgia; tremor; impotence.

Warnings and Precautions

Hypotension, poor cardiac reserve, heart failure. Sudden withdrawal may exacerbate angina. Discontinue in patients who experience ischemic pain following administration. Pregnancy, lactation.

Contraindications

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Drug Interactions

Other antihypertensives; aldesleukin; antipsychotics that cause hypotension; may modify insulin and glucose responses; quinidine; carbamazepine; phenytoin; rifampicin; cimetidine; erythromycin.

Overdosage

–

Storage

–

Mechanism of Action

Cilnidipine is a dihydropyridine calcium-channel blocker. It inhibits cellular influx of calcium, thus causing vasodilatation. It has greater selectivity for vascular smooth muscle. It has little or no action at the SA or AV nodes and -ve inotropic activity is rarely seen at therapeutic doses.

References

https://www.mims.com/india/drug/info/cilnidipine/?type=full&mtype=generic#Indications

https://pubchem.ncbi.nlm.nih.gov/compound/5282138#section=Protein-Binding

http://www.jbcpl.com/about/index.html

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