DEFMO

Dosage : Tablets
Contains : Dimethyl fumarate
Category : Neurological
Uses : Multiple Sclerosis
Price :

Demfo is prescribed for the management of Multiple Sclerosis to make it a hassle-free and pain-free process since it comes in a tablet form. It contains Dimethyl fumarate which is used to treat relapsing forms of Multiple sclerosis (MS). It is classified as a disease-modifying therapy for MS and aids in decreasing the number of episodes of worsening MS.

 

Dimethyl Fumarate in Demfo helps in slowing down MS. This medication works by changing the working of the body’s immune system. It prevents new brain lesions and lowers the number of attacks making them less severe. It greatly reduces the risk of MS relapse as well as the risk of worsening physical disability.

 

Demfo is manufactured by Dr. Reddy’s Laboratories (DRL) an Indian multinational pharmaceutical company based in Hyderabad,  India. The company has a state-of-the-art R&D Centre spread over 300,000 sq. ft.  housing 70 laboratories with over 800 research scientists working on various projects. It offers a wide-ranging suite of capabilities and services, from synthetic organic chemistry to formulations development; intellectual property management, regulatory science, polymorphism and bio-pharmaceutics.

Multiple sclerosis or MS is a disease affecting the brain, spinal cord and the optic nerves in the eyes. It can create problems related with muscle control, balance and vision.

 

In MS, your immune system attacks myelin, a fatty material which wraps around nerve fibres to protect them. This results in damage to your nerves and formation of scar tissue. Due to the damage your brain is not able to send the correct signals to your body and movement is often affected. Common symptoms of MS include tiredness, muscle weakness or spasms, pain, trouble walking, blurred vision, memory loss, numbness and tingling sensation, poor bladder and bowel control and depression.

 

Overtime, when MS symptoms get worse, most people have relapses. It can be followed by times of recovery when symptoms improve or due to lack of treatment, the condition can continue to deteriorate.

MS condition develops in people with certain genes who may have higher chances of getting it. Smoking increases the chances while a viral infection can trigger the disease or cause a relapse. Vitamin D from the sunlight strengthens the immune system and helps to protect against MS.

 

To diagnose MS, doctors may suggest blood tests and checks of your body balance, muscle coordination, vision and other functions to see how well your nerves are working.  MRI may be conducted along with  tests called Evoked Potentials that measure the electrical activity in your brain. For treating MS, you may be prescribed drugs that prevent attacks, slow the course of the disease and ease symptoms that appear with the condition.

Dosage

As directed by physician

Administration

As directed by physician

Adverse Reactions/ Side Effects

Warnings and Precautions

Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect.

 

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

 

A very bad brain problem called progressive multifocal leukoencephalopathy (PML) has occurred with dimethyl fumarate. It may cause disability or can be deadly. Tell your doctor right away if you have signs like confusion, memory problems, low mood (depression), change in the way you act, change in strength on 1 side is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.

 

Low white blood cell counts have rarely happened with dimethyl fumarate. This may lead to a higher chance of getting an infection. Tell your doctor if you have ever had a low white blood cell count. Call your doctor right away if you have signs of infection like fever, chills, or sore throat.

Liver problems have happened. Call your doctor right away if you get signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colour stools, throwing up, or yellow skin or eyes.

 

Tell all of your health care providers that you take dimethyl fumarate. This includes your doctors, nurses, pharmacists, and dentists.

 

Have blood work checked as you have been told by the doctor. Talk with the doctor.

 

Herpes zoster (shingles) and other severe infections have occurred with dimethyl fumarate. Sometimes, these infections have affected the brain, nerves, and other areas of the body. Talk with your doctor about what signs to watch for.

Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

Contraindications

Drug Interactions

Overdosage

Storage

Store at room temperature protected from light. Store in a dry place. Do not store in a bathroom.

 

Store in original container.

 

Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.

 

Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Mechanism of Action

References

https://www.webmd.com/drugs/2/drug-163864/dimethyl-fumarate-oral/details

https://www.webmd.com/multiple-sclerosis

https://www.drreddys.com

https://www.drugs.com/cdi/dimethyl-fumarate.html

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