DYTOR

Dosage : Tablet
Contains : Torasemide
Category : Diuretics
Uses : Hypertension, Oedema
Price :

Torasemide is a high-ceiling loop diuretic. High ceiling loop diuretic means it inhibits

body’s ability to reabsorb sodium at the ascending loop in the nephron (the functional unit) of Kidney. This leads to rapid and marked excretion of water, sodium and chloride. The mechanism of action of Dytor facilitates reduction of oedema and high BP.

 

It is prescribed in the following conditions:

  • Hypertension
  • Oedema in patients with liver cirrhosis
  • Oedema

 

Dytor is a product of Cipla limited which is an Indian multinational pharmaceutical and biotechnology company. It is primarily into development of medicines to treat respiratory, cardiovascular disease, arthritis, diabetes, weight control, depression and other medical conditions. The company’s goal is ensuring that no patient shall be denied access to high quality and affordable medicines and support with the vision to make India self-sufficient in health care.

High blood pressure

High BP is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.

There are two types of high blood pressure.

 

Primary (essential) hypertension

For most adults, there’s no identifiable cause of high blood pressure. This type of high blood pressure, called primary (essential) hypertension, tends to develop gradually over many years.

 

Secondary hypertension

Some people have high blood pressure caused by an underlying condition. This type of high blood pressure, called secondary hypertension, tends to appear suddenly and cause higher blood pressure than does primary hypertension. Various conditions and medications can lead to secondary hypertension, including:

  • Obstructive sleep apnea
  • Kidney problems
  • Adrenal gland tumors

 

Uncontrolled high blood pressure can lead to complications including:

Heart attack or stroke. High blood pressure can cause hardening and thickening of the arteries (atherosclerosis), which can lead to a heart attack, stroke or other complications.

 

Aneurysm

Increased blood pressure can cause your blood vessels to weaken and bulge, forming an aneurysm. If an aneurysm ruptures, it can be life-threatening.

 

Heart failure

To pump blood against the higher pressure in your vessels, the heart has to work harder. This causes the walls of the heart’s pumping chamber to thicken (left ventricular hypertrophy). Eventually, the thickened muscle may have a hard time pumping enough blood to meet your body’s needs, which can lead to heart failure.

Dosage

As directed by physician

Administration

As directed by physician

Adverse Reactions/ Side Effects

Electrolyte disturbances e.g. hypokalaemia, dehydration, dry mouth, headache, dizziness, hypotension, weakness, drowsiness, confusional states, loss of appetite, cramps, increased serum uric acid, glucose, lipids, urea and creatinine, increase in LFT, metabolic alkalosis, tinnitus and hearing loss.

Warnings and Precautions

 Risk of hyperuricaemia, gout and DM. Correct electrolyte distubances and disorders of micturition before treatment. Monitor electrolyte balance, glucose, uric acid, creatinine and lipids regularly. May impair ability to drive or operate machinery.

Contraindications

Hypersensitivity to sulfonylureas, renal failure with anuria, hepatic coma and pre-coma, hypotension, cardiac arrhythmias. Pregnancy and lactation.

Drug Interactions

Increased risk of severe hypokalaemia with amphotercin B, corticosteroids, carbenoxolone, hypokalaemia-causing medications. Increased risk of lithium toxicity. Increased potential for ototoxicity and nephrotoxicity with nephrotoxic or ototoxic medications e.g. aminoglycosides. High dose salicylates may increase the risk of salicylate toxicity. Increased risk of toxicity with digoxin. Reduced diuretic effect with NSAIDs. Increased risk of hypotension with antihypertensives.

Overdosage

Symptoms: Marked diuresis with severe dehydration and electrolytes disturbances. Somnolence, confusion, hypotension, circulatory collapse and GI disturbances. Management: Reduce or stop torasemide. There is no antidote and treatment involves simultaneous replacement of fluid and electrolytes. Haemodialysis unlikely to be useful.

Mechanism of Action

Torasemide, a sulfonylurea loop diuretic, acts from within the lumen of the thick ascending portion of the loop of Henle, where it inhibits the Na+/K+/2CI–carrier system.

References

https://www.mims.com/india/drug/info/torasemide/type=full&mtype=generic#Indications

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