GESNAC P

Dosage : Tablets
Contains : Paracetamol + Aceclofenac
Category : Pain Management
Uses : Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis
Price :

Gesnac P is prescribed to help treat pain and inflammation for patients suffering from rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It also helps relieve mild to moderate pain in case of headache, toothache, muscle pain or back pain.

 

Gesnac P works by blocking the release of certain chemical messengers that result in inflammation, redness, pain and fever. Gesnac P contains Aceclofenac which is a non-steroidal anti-inflammatory drug (NSAID). It is reported to have a higher anti-inflammatory action and better or comparable effects than conventional NSAIDs. Aceclofenac acts by inhibiting the cyclo-oxygenase enzyme (COX) that create prostaglandins. Prostaglandins are inflammatory mediators that cause pain, swelling, inflammation and fever. Gesnac P also contains Paracetamol which selectively inhibits the COX enzymes in the brain helping in increasing the pain threshold.

 

Gesnim P is manufactured by Aarpik Pharmaceuticals Pvt. Ltd, based in Ahmedabad, Gujarat, India. Established in the year 1993, Aarpik is a leading manufacturer of a wide range of Pharmaceutical Tablets, Pharmaceutical Capsules, Syrups and Protein Powders and also renders Third Party manufacturing for its clients. The company has a wide and well functional infrastructural unit that offers these products at reasonable rates and delivers them within the promised time-frame.

Rheumatoid Arthritis, Osteoarthritis and Ankylosing Spondylitis.

 

Rheumatoid arthritis is an autoimmune disease which occurs when a person’s immune system mistakenly attacks healthy tissues in the joints.

 

In Osteoarthritis, the protective cartilage gradually wears down as the bones at the joints begin to scrape against one another due to repetitive movements and unnecessary pressure on joints. Rheumatoid arthritis occurs in smaller joints of the body, while Osteoarthritis is seen in bigger joints like hip and knee joints.

 

Some of the symptoms of Rheumatoid Arthritis are fatigue, fever, loss of appetite, rheumatoid nodules, weight loss and inflammation in other areas such as the eyes and lungs.

 

Those suffering from Osteoarthritis can develop bone spurs or other bone abnormalities.

 

Treatment for Rheumatoid and Osteoarthritis includes medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce inflammation, alleviate pain and stiffness in the joints and improve their range of motion. Physiotherapy may also be suggested to keep the joints flexible and help improve a person’s mobility.

 

Ankylosing spondylitis (AS) is a type of arthritis that affects the spine causing pain, stiffness, and inflammation from the neck to lower back. In AS, the vertebrae in your spine can fuse together making it less flexible and causing a hunched-over posture and difficulty in breathing.

 

Treatment for AS include nonsteroidal anti-inflammatory drugs (NSAIDs), Corticosteroid shots in your joints, Disease-modifying anti rheumatic drugs (DMARDs), Biologic DMARDs. Surgery may be recommended for a curved spine or neck, damaged knees and hips.

Dosage

As directed by physician

Administration

As advised by physician

Adverse Reactions/ Side Effects

Paracetamol: Nausea, allergic reactions, skin rashes, acute renal tubular necrosis. Aceclofenac: Diarrhoea, headache, vertigo, dizzies, nervousness, tinnitus, depression, drowsiness, insomnia; fever, angioedema, bronchospasm, rashes; blood dyscrasias.

Potentially Fatal: Paracetamol: Very rare, blood dyscrasias (eg, thrombocytopaenia, leucopaenia, neutropaenia, agranulocytosis); liver damage. Aceclofenac: Severe GI bleeding; nephrotoxicity.

Warnings and Precautions

GI disease; renal or hepatic impairment; alcohol-dependent patients; asthma or allergic disorders; haemorrhagic disorders; hypertension; cardiac impairment. Elderly. Caution when driving or operating machinery. Monitor renal and hepatic function and blood counts during long term treatment. Persistently elevated hepatic enzyme levels may require drug withdrawal. Pregnancy, lactation.

Contraindications

Hypersensitivity. Moderate to severe renal or hepatic impairment; severe heart failure; pregnancy (third trimester).

Drug Interactions

Paracetamol: Reduced absorption of cholestyramine within 1 hr of administration. Accelerated absorption with metoclopramide. Aceclofenac: M0ay increase the plasma concentrations of lithium and digoxin. Increased nephrotoxicity with diuretics. Serum-potassium should be monitored when used with potassium-sparing diuretics. May enhance activity of anticoagulants. May increase plasma methotrexate levels leading to toxicity if administered within 2-4 hr of methotrexate admin. Risk of convulsions with quinolones.

 

Potentially Fatal: Paracetamol: Increased risk of liver damage in chronic alcoholics. Increased risk of toxicity with high doses or long term admin of barbiturates, carbamazepine, hydantoins, isoniazid, rifampin and sulfinpyrazone.

Overdosage

Empty stomach promptly by gastric lavage or induction of emesis. Administer standard supportive measures.

Storage

–

Mechanism of Action

Aceclofenac is a phenylacetic acid derivative that inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. It increases glycosaminoglycans (GAG) synthesis, the principal macromolecule of the extracellular matrix, which aids in repair and regeneration of articular cartilage. Thus, aceclofenac has +ve effects on cartilage anabolism combined with modulating effect of matrix catabolism. Paracetamol has analgesic and antipyretic action with weak anti-inflammatory activity. It produces analgesia by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating centre.

References

https://www.practo.com/medicine-info/gesnac-p-500-100-mg-tablet-39918

https://www.drugbank.ca/drugs/DB06736

https://www.1mg.com/generics/aceclofenac-paracetamol-acetaminophen-400014

https://www.medicalnewstoday.com/articles/323617.php

https://www.webmd.com/arthritis/what-is-ankylosing-spondylitis

https://www.indiamart.com/aarpik-pharmaceuticals/profile.html

https://www.mims.com/india/drug/info/aceclofenac%20%2b%20paracetamol/?type=full&mtype=generic#Indications

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