| Dosage | : | Tablets |
| Contains | : | Nimesulide + Paracetamol |
| Category | : | Pain Management |
| Uses | : | Osteoarthritis, Rheumatoid Arthritis, Ankylosing Spondylitis and Menstrual cramps |
| Price | : |
Gesnim P is prescribed to help treat pain and inflammation for patients suffering from rheumatoid arthritis, osteoarthritis, ankylosing spondylitis and menstrual cramps. It is also used to treat mild to moderate pain caused due to sprains and strains of joints and muscles
Gesnim P is a combination of two medicines: Nimesulide and Paracetamol. Nimesulide is a fast acting and potent nonsteroidal anti-inflammatory drug (NSAID). It works by blocking the release of certain chemical messengers that result in inflammation, redness, swelling, pain and fever. Gesnim P also contains Paracetamol which selectively inhibits the COX enzymes in the brain helping in increasing the pain threshold.
Gesnim-P is manufactured by Aarpik Pharmaceuticals Pvt. Ltd, based in Ahmedabad, Gujrat, India. Established in the year 1993, Aarpik is a leading manufacturer of a wide range of Pharmaceutical Tablets, Pharmaceutical Capsules, Syrups and Protein Powders and also renders Third Party manufacturing for its clients. The company has a wide and well functional infrastructural unit that offers these products at reasonable rates and delivers them within the promised time-frame.
Arthritis, Osteoarthritis Ankylosing Spondylitis and menstrual cramps.
Rheumatoid arthritis is an autoimmune disease which occurs when a person’s immune system mistakenly attacks healthy tissues in the joints.
In Osteoarthritis, the protective cartilage gradually wears down as the bones at the joints begin to scrape against one another due to repetitive movements and unnecessary pressure on joints. Rheumatoid arthritis occurs in smaller joints of the body, while Osteoarthritis is seen in bigger joints like hip and knee joints.
Some of the symptoms of Rheumatoid Arthritis are fatigue, fever, loss of appetite, rheumatoid nodules, weight loss and inflammation in other areas such as the eyes and lungs.
Those suffering from Osteoarthritis can develop bone spurs or other bone abnormalities.
Treatment for Rheumatoid and Osteoarthritis includes medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce inflammation, alleviate pain and stiffness in the joints and improve their range of motion. Physiotherapy may also be suggested to keep the joints flexible and help improve a person’s mobility.
Ankylosing spondylitis (AS) is a type of arthritis that affects the spine causing pain, stiffness, and inflammation from the neck to lower back. In AS, the vertebrae in your spine can fuse together making it less flexible and causing a hunched-over posture and difficulty in breathing.
Treatment for AS include nonsteroidal anti-inflammatory drugs (NSAIDs), Corticosteroid shots in your joints, Disease-modifying anti rheumatic drugs (DMARDs), Biologic DMARDs. Surgery may be recommended for a curved spine or neck, damaged knees and hips.
Menstrual cramps or Dysmenorrhea are caused by uterine contractions. Primary dysmenorrhea refers to common menstrual cramps, while secondary dysmenorrhea results from a disorder in the reproductive organs. Primary dysmenorrhea is common menstrual cramps that are recurrent. Pain usually begins 1 or 2 days before or when menstrual bleeding starts and is felt in the lower abdomen, back or thighs. Pain can range from mild to severe, can typically last 12 to 72 hours and can be accompanied by nausea, vomiting, fatigue or diarrhoea.
Secondary dysmenorrhea is pain that is caused by a disorder in the woman’s reproductive organs, such as endometriosis, adenomyosis, uterine fibroids or infection. Pain from secondary dysmenorrhea usually begins earlier in the menstrual cycle and lasts longer than common menstrual cramps.
To relieve mild menstrual cramps you may take a pain reliever or an anti-inflammatory medication. Massage your lower back and abdomen. Avoid foods that contain caffeine, avoid smoking and drinking alcohol.
Dosage
As directed by physician
Administration
As directed by physician
Adverse Reactions/ Side Effects
Epigastric discomfort, heartburn or abdominal cramps, nausea, vomiting and diarrhoea; skin rash, pruritus, oedema, headache, dizziness, drowsiness; hypersensitivity reactions (e.g. bronchospasm, rhinitis, angioedema urticaria); GI haemorrhage/perforation; bullous/erosive stomatitis, purpura, thrombocytopenia, toxic epidermal necrolysis, haematuria, oliguria, and renal failure; increases in liver enzymes.
Potentially Fatal: Fatal hepatitis, Stevens Johnson syndrome.
Warnings and Precautions
History of GI tract disease, infections, oedema, hypertension, elderly, lactation.
Contraindications
Hypersensitivity; GI bleeding, active peptic ulcer disease; severe renal and heart failure; hepatic impairment or known liver disease; coagulation disorders; pregnancy; children <12 yr.
Drug Interactions
Additive hepatotoxic effects with known hepatotoxins: anti-convulsants (e.g. valproic acid), anti-fungals (e.g. ketoconazole), anti-tuberculous drugs (e.g. isoniazid), tacrine, pemoline, amiodarone, methotrexate, methyldopa, amoxicillin/clavulanic acid. May decrease the oral bioavailability of furosemide and the natriuretic and diuretic response to furosemide. Increased risks of GI and hepatic adverse effects with other NSAIDs, including aspirin. May increase anti-coagulant effect of warfarin. Potentiates the action of phenytoin. May be displaced from binding sites with fenofibrate, salicylic acid, and tolbutamide. Interactions between NSAIDs and lithium, probenecid and ciclosporin, have been documented.
Overdosage
Epigastric pain, nausea, vomiting, drowsiness, lethargy, GI haemorrhage, seizures, hypertension, apnoea, coma, anaphylactic reactions and renal failure. Treatment is supportive.
Storage
Protect from heat and humidity; store at <25°C.
Mechanism of Action
Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, anti-pyretic, and analgesic properties. It inhibits prostaglandin synthetase/cyclooxygenase, which limits prostaglandin production. Its cyclooxygenase inhibiting potency is intermediate, but is relatively selective for the cyclo-oxygenase-2 (COX-2) thus the potential for gastric injury and intolerance is less. It is also a free radical scavenger, and helps protect against the tissue damage that occurs during inflammation.
References
https://www.1mg.com/generics/nimesulide-paracetamol-acetaminophen-402515
https://my.clevelandclinic.org/health/diseases/4148dysmenorrheahttps://www.medicalnewstoday.com/articles/323617.ph
phttps://www.webmd.com/arthritis/what-is-ankylosingspondylitis
https://www.indiamart.com/aarpikpharmaceuticals/profile.html
https://www.ndrugs.com/?s=gesnim-p&t=dosage