Humalog Mix is a premixed suspension consisting of insulin lispro (fast-acting human insulin analogue) and insulin lispro protamine suspension (intermediate acting human insulin analogue). Humalog Mix is available as pre-filled pen and suspension for injection.
It is available in two strengths Humalog Mix-25 and Humalog Mix-50.
Humalog Mix is indicated for the treatment of patients with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis.Insulin lispro has a rapid onset of action (approximately 15 minutes), hence it can be given closer to a meal (within zero to 15 minutes of the meal). One unit of insulin lispro has been shown to be as potent as one unit of human insulin in lowering glucose.
Insulin lispro protamine is an intermediate acting insulin enabling blood glucose control for longer duration, also during night time.
These two in combination provide 24-h coverage and the control of post-meal glucose concentration while limiting the number of daily injections.
Humalog Mix is a brand of Eli Lilly and Company, a global, research-based company founded in 1876. For more than 140 years, Eli Lilly & Company has discovered, developed and acquired innovative new medicines that address key unmet medical needs worldwide. It has remained dedicated to creating medicines that help improve peoples’ quality of life.
Since inception, Lilly India is offering advanced treatment options to treat chronic diseases such as diabetes, lung cancer, gastric cancer, osteoporosis, men’s health and growth-hormone deficiency.
Diabetes occurs when your blood glucose (blood sugar) is too high.
Blood glucose is your main source of energy and it comes from the food you consume. Your pancreas produces a hormone called insulin, which helps convert the glucose from your food to energy by carrying it into your cells.
In a diabetic patient, their body doesn’t produce enough insulin or doesn’t manage insulin well. Glucose then accumulates in your blood and doesn’t reach your cells causing a host of health problems and diseases that may include:
Pregnancy (insulin requirements tend to fall during the 1st trimester, increase during the 2nd and 3rd) and lactation. Regular monitoring of HbA1c and blood glucose concentrations.
Possible absence of hypoglycaemic warning symptoms with β-blockers. Decreased hypoglycaemic effect with corticosteroids, danazol, diazoxide, diuretics, glucagon, isoniazid, phenothiazine derivatives, somatropin, sympathomimetic agents, thyroid hormones, oestrogens, progestins (e.g. in oral contraceptives), protease inhibitors and atypical antipsychotic (e.g. olanzapine and clozapine). Increased hypoglycaemic effect with oral antidiabetic agents, ACE inhibitors, disopyramide, fibrates, fluoxetine, MAOIs, pentoxifylline, propoxyphene, salicylates and sulfonamide antibiotics. Decreased insulin resistance with octreotide and lanreotide. Increased risk of wt gain and peripheral oedema with pioglitazone, rosiglitazone. Decreased effect of sermorelin.
Symptoms: Hypoglycaemia. Management: In mild hypoglycaemic episodes, treat with oral glucose. In severe hypoglycaemic episodes, where the patient has become unconscious, treat with IM/SC glucagon (0.5-1 mg) or IV glucose. If the patient does not respond to glucagon within 10-15 minutes, IV glucose must be given. Once consciousness is regained, admin oral carbohydrates to prevent a relapse.
Mechanism of Action
Insulin lowers blood glucose levels. It regulates carbohydrate, protein and fat metabolism by inhibiting hepatic glucose production and lipolysis, and enhancing peripheral glucose disposal. The various insulin formulations are classified according to their durations of action after subcutaneous injection.
They are divided into short-, intermediate-, or long-acting insulin. Soluble insulin (also known as ‘neutral insulin’ or ‘regular insulin’) is a short-acting preparation. To extend the duration of action of insulin, preparations are formulated as suspensions in 2 methods. The 1st method involves complexing insulin with a protein so that it is slowly released, e.g. protamine zinc insulin (contains an excess of protamine) and isophane insulin (or NPH insulin which contains equal amounts of protamine and insulin). An alternative method is particle size modification e.g. insulin zinc suspensions. While all the formulations can be admin by SC injection, most by IM injection, only soluble insulin can be admin by IV. Compared to SC injection, IM administration usually has a faster onset of action, with a shorter duration of action.