IVABRAND

Dosage : 7.5 mg, 5 mg
Contains : Ivebradine
Category : Antianginal drugs
Uses : Angina
Price :

Ivabrad 5 Tablet is used to treat chronic heart failure (a condition where the heart does not pump the blood adequately) and stable angina (chest pain or discomfort). This medicine is not recommended for use in patients less than 18 years of age.

 

Ivabrad is product of Lupin. Lupin Limited, headquartered in Mumbai, India, is strongly research focused. The company has a state-of-the-art R&D center in Pune and is a leading global player in Anti-TB, Cephalosporins (anti-infectives) and Cardiovascular drugs (ACE-inhibitors and cholesterol reducing agents) and has a notable presence in the areas of diabetes, anti-inflammatory and respiratory therapy.

Angina pectoris

 

Angina pectoris is the medical term for chest pain or discomfort due to coronary heart disease.  It occurs when the heart muscle doesn’t get as much blood as it needs. This usually happens because one or more of the heart’s arteries is narrowed or blocked, also called ischemia.

 

Angina usually causes uncomfortable pressure, fullness, squeezing or pain in the center of the chest.

 

The pain or discomfort occurs when the heart must work harder, usually during physical exertion. Doesn’t come as a surprise, and episodes of pain tend to be alike. It usually lasts a short time (5 minutes or less)

Dosage

As directed by physician

Administration

As directed by physician

Adverse Reactions/ Side Effects

Luminous phenomena in the visual field (phosphenes), blurred vision, bradycardia, other cardiac arrhythmias, syncope, hypotension, asthenia, fatigue, headache, dizziness, nausea, constipation, diarrhoea, dyspnoea, muscle cramps, skin reactions, angioedema, hyperuricaemia, eosinophilia, elevated blood-creatinine concentrations.

Warnings and Precautions

–

Contraindications

–

Drug Interactions

QT prolongation may be exacerbated by heart rate reduction w/ QT-prolonging drugs (e.g. quinidine, disopyramide, pimozide, ziprasidone). Concentration may be reduced w/ CYP3A4 inducers (e.g. rifampicin, barbiturates, phenytoin) and may require ivabradine dose adjustment.

 

Potentially Fatal: Increased serum concentration w/ potent CYP3A4 inhibitors (e.g. azole antifungals, macrolides, HIV protease inhibitors or nefazodone), moderate CYP3A4 inhibitors (e.g. verapamil or diltiazem).

Overdosage

Symptoms: Severe and prolonged bradycardia. Management: Treat severe bradycardia symptomatically. In case of bradycardia w/ poor haemodynamic tolerance, IV β-stimulating medicines e.g. isoprenaline may be used. If necessary, may institute temporary cardiac electrical pacing.

Storage

Store at 25°C.

Mechanism of Action

Ivabradine is a heart rate lowering agent that works through selective and specific inhibition of the cardiac pacemaker If current that controls the spontaneous diastolic depolarisation in the sinus node and regulates heart rate.

References

https://www.mims.com/india/drug/info/ivabrad/ivabrad%20film-coated%20tab

https://www.practo.com/medicine-info/ivabrad-5-tablet-46580

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