| Dosage | : | Tablet |
| Contains | : | Losartan and Hydrochlorothiazide |
| Category | : | Angiotensin II Antagonist with Diuretic |
| Uses | : | Hypertension |
| Price | : |
Losar-H is a medicine prescribed for hypertension and the composition is Losartan and Hydrochlorothiazide.
Causes of Hypertension are variable and differs from individual to individual.One of the prime cause of hypertension includes, increased or inappropriate secretion of renin, an enzyme secreted by kidneys. Secretion of renin results in increased production of a hormone called angiotensin II. Angiotensin causes blood vessels to constrict thereby increasing the blood pressure. It further stimulates the release of aldosterone in body causing sodium retention by the kidneys resulting in further rise of blood pressure.
Losar-H deals with hypertension in two ways.
Losartan blocks the actions of angiotensin II of renin-angiotensin-aldosterone system. This reduces the high blood pressure. Hydrochlorothiazide increases excretion of sodium and chloride by kidneys. This helps in reducing the load on heart.
Losar-H is manufactured and distributed by Torrent Pharmaceuticals Ltd. Torrent Pharma, the flagship Company of Torrent Group is one of the leading pharma companies of India. It is ranked amongst the leaders in therapeutic segment of Cardiovascular (CV) and Central Nervous System (CNS).
Torrent pharma has world-class manufacturing facilities, advanced R & D capabilities, extensive domestic network and a widespread global presence in over 40 countries.
Your doctor may have prescribed Losar H because you could be suffering from Hypertension.
Losar H is an orally available medication that contains Losartan and Hydrochlorothiazide. It works by blocking the effect of angiotensin, a protein whose presence in the blood promotes secretion of a hormone tends to raise blood pressure.This makes your blood vessels relax more. It also allows your kidney to get rid of excess water and salt.
Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems.It is a major risk factor for coronary heart disease and a cause of heart attacks. A build-up of cholesterol is part of the process that narrows arteries, called atherosclerosis, in which plaques form and cause restriction of blood flow leading to high blood pressure.
In a hypertension patient, blood pressure is the force exerted by the blood against the walls of the blood vessels. Losar H can be used to treat hypertension, which if unattended can cause a host of health problems and diseases that may include:
- Hypertriglyceridemia
- Cardiovascular diseases
- Stroke
Losar H has been proven to work well among patients with high blood pressure, which in turn leads to coronary diseases.
Dosage
As directed by physician
Administration
As directed by physician
Adverse Reactions/ Side Effects
Volume depletion and electrolyte imbalance (especially hyperkalaemia); dry mouth, thirst; lethargy, drowsiness; muscle pain and cramps; rashes, photosensitivity, thrombocytopenia, jaundice, pancreatitis; fatigue, weakness; may precipitate an attack of gout; impotence; hyperglycaemia; anorexia, nausea, vomiting, constipation, diarrhoea; sialdenitis; raised urinary calcium concentration; headache, dizziness; back pain, myalgia; first-dose hypotension; angiodema; neutropenia; GI disturbances; transient elevation of liver enzymes; taste disturbances, cough; exacerbation or activation of systemic lupus erythematous; palpitations; xanthopsia; leucopenia, agranulocytosis, aplastic anaemia; necrotising angiitis; glucosuria; renal dysfunction, interstitial nephritis, renal failure; migraine; hyponatraemia; UTI; chest pain; gastritis, wt gain, dyspepsia, abdominal pain; bronchitis, upper respiratory infection, nasal congestion, sinusitis; rise in cholesterol and/or triglycerides.
Potentially Fatal: Hypersensitivity reactions; hemolytic anaemia; toxic epidermal necrolysis.
Warnings and Precautions
Existing electrolyte disturbances; hepatic cirrhosis; severe hepatic failure; oedema; elderly (>75 yr); renal impairment; hepatic impairment; diabetes, gout, hyperlipidaemia; hyperuricaemia; ECG: LVH and/or ventricular ectopics extrasystoles); volume depleted patients; patients on diuretics and salt restriction; renal artery stenosis; aortic and mitral stenosis. Monitor potassium concentration. Discontinue before performing tests for parathyroid function.
Contraindications
Pregnancy, lactation; intravascular volume depletion.
Drug Interactions
Hydrochlorothiazide increases plasma concentration fluconazole. Increased hypotensive effect with: ACE inhibitors, alcohol, adrenergic neurone blockers, aldesleukin, α-blockers, alprostadil, general anaesthetics, antipsychotics, anxiolytics and hypnotics, baclofen, β-blockers, calcium-channel blockers, clonidine, diazoxide, epoetin, hydralazine, levodopa, MAOIs, methyldopa, minoxidil, monoxidine, nitrates, NSAIDs, oestrogens, sodium nitroprusside, tizanidine, phenothiazines. Increased risk of renal impairment with aspirin (in doses >300 mg daily), NSAIDs. Hypotensive effect antagonised by aspirin, corticosteroids, indomethacin, ketorolac.
Increased risk of hyperkalaemia with potassium-sparing and aldosterone antagonists, drospirenone (monitor serum potassium during 1st cycle), epoetin, heparin, ketorolac, potassium salts. Increased risk of hypersensitivity with allopurinol (especially in renal impairment). May antagonise hypoglycaemic effects of antidiabetics. Increased risk of hypercalcaemia with calcium salts and vitamin D. Increased risk of hyponatraemia with chlorpropamide. Increased risk of hypermagnesaemia with ciclosporin. Absorption may be reduced by colestipol and colestyramine (take at least 2 hr apart).
Potentially Fatal: Increased risk of nephrotoxicity and ototoxicity with platinum compounds, aminoglycosides. Hypokalaemia caused by diuretics may cause cardiac toxicity with amiodarone (interaction may occur for several weeks or months due to long half life of amiodarone). Increased risk of nephrotoxicity and hyperkalaemia with ciclosporin. Reduced excretion of lithium (risk of lithium toxicity with diuretics).
Overdosage
Symptoms: hypotension and tachycardia. Treatment: supportive and symptom specific. Not removed via haemodialysis.
Storage
Protect from light and store at 15-30 °C.
Mechanism of Action
Hydrochlorothiazide increases renal excretion of sodium and chloride and reduces cardiac load. Losartan is an angiotensin II receptor (type AT1) antagonist antihypertensive which acts by blocking the actions of angiotensin II of renin-angiotensin-aldosterone system. The drug and its active metabolite selectively block the vasoconstrictor and aldosterone secreting effects of angiotensin II. The two drugs exert additive effects in hypertension.
References
https://www.mims.com/india/drug/info/losartan%20%2b%20hydrochlorothiazide/?type=full&mtype=generic#Indications