Dosage : 75, 150 mg Capsule
Contains : Pregabalin
Category : Anticonvulsant
Uses : Neuropathic pain, partial seizures
Price :

Lyrica contains Pregabalin. Pregabalin is an anticonvulsant drug used for neuropathic pain and as an adjunct therapy for partial seizures with or without secondary generalization in adults.


Lyrica is product of Pfizer Inc. Pfizer is an American multinational pharmaceutical corporation headquartered in New York City.


On December 19, 2018, Pfizer announced a joint merger of their consumer healthcare division with UK pharma giant GlaxoSmithKline; the British company will maintain a controlling share


The company developed and produces medicines and vaccines for a wide range of medical disciplines, including immunology, oncology, cardiology, endocrinology, and neurology.

Peripheral neuropathy

Peripheral neuropathy is a disorder that occurs when these nerves malfunction because they’re damaged or destroyed. This disrupts the nerves’ normal functioning. They might send signals of pain when there’s nothing causing pain, or they might not send a pain signal even if something is harming you. This can be due to:

  • an injury
  • systemic illness
  • an infection
  • an inherited disorder
  • The disorder is uncomfortable, but treatments can be very helpful. The most important thing to determine is whether peripheral neuropathy is the result of a serious underlying condition.


As directed by physician


As directed by physician

Adverse Reactions/ Side Effects

Dizziness, drowsiness, visual disturbance (including blurred vision, diplopia), ataxia, dysarthria, tremor, lethargy, memory impairment, euphoria, wt gain, constipation, dry mouth, peripheral edema, depression, confusion, agitation, hallucinations, myoclonus, hypoaesthesia, hyperaesthesia, tachycardia, excessive salivation, sweating, flushing, rash, muscle cramp, myalgia, arthralgia, urinary incontinence, dysuria, thrombocytopenia, neutropenia, 1st ° heart block, hypotension, hypertension, pancreatitis, dysphagia, oliguria, rhabdomyolysis.

Warnings and Precautions

Discontinue treatment if patients develop severe angioedema. Withdraw treatment gradually over at least 1 week. May cause peripheral oedema. Regular vision check is recommended. May decrease platelet count and prolong PR interval.


Contraindicated in pregnancy

Contraindicated in lactation

Pregabalin and Children- Safety and efficacy not established

Pregabalin and Geriatic- Because of age-related renal function impairment, dosage adjustment may be needed.

Pregabalin and Other Contraindications- Hypersensitivity. Pregnancy, lactation. Driving or working with machines, or do other dangerous activities.

Drug Interactions

Concurrent use with oxycodone, lorazepam and ethanol may increase the CNS effects.


Symptoms: Somnolence, confusional state, agitation, restlessness, and seizures. Rarely, coma. Management: Symptomatic and supportive treatment. May be removed by haemodialysis. Consider administration of activated charcoal if ingestion is within 1 hour.


Store at 25°C

Mechanism of Action

Like gabapentin, pregabalin binds to the α2δ (alpha2delta) subunit of the voltage-dependent calcium channel in the central nervous system. This reduces calcium influx into the nerve terminals. Pregabalin also decreases the release of neurotransmitters such as glutamate, noradrenaline, and substance P (Australian Medicines Handbook). Pregabalin increases neuronal GABA levels by producing a dose-dependent increase in glutamic acid decarboxylase activity. Glutamic acid decarboxylase (GAD) is the enzyme that converts the excitatory neurotransmitter glutamate into the inhibitory GABA in a single step. For this reason, pregabalin greatly potentiates benzodiazepines, barbiturates & other depressants.


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