Dosage : Tablet
Contains : Teneligliptin and Metformin
Category : Ant diabetic agent
Uses : Type 2 Diabetes
Price :

Megagliptin MF is a combination of a Teneligliptin and Metformin for the treatment of Type 2 diabetes. It is the smallest tablet in the Teneligliptin and Metformin combination category.


Teneligliptin belongs to class of drugs called DPP4 inhibitor.


Metformin works by decreasing glucose production by liver, decreasing glucose absorption in the gastro-intestinal tract and increasing insulin sensitivity of the cells.


The combination is also available as Megagliptin MFFORTE.


Megagliptin MF is manufactured by Aristo Pharmaceuticals Pvt. Ltd. Since its inception in 1971, Aristo Pharmaceuticals is supporting medical profession in promoting and preserving good health. Aristo Pharmaceuticals is one of the Top 10 pharmaceutical companies of India delivering world class quality products.

Type 2 diabetes


Megagliptin MF is prescribed to patients withType-2 Diabetes. It is an orally available combination medicine of Teneligliptin and Metformin. Teneliglitin increases the count of natural substances known as incretins which in turn helps increase insulin release by the pancreas while decreasing the production of glucose by your liver. Metformin helps restore your cell’s response to the naturally produced insulin in your body.


Blood glucose is the main source of energy and it comes from the food you consume. Your pancreas produces a hormone called insulin, which helps convert the glucose from your food to energy by carrying it inside your cells.


In type-2 diabetes patients, their body doesn’t produce enough insulin or doesn’t manage insulin well due to the inefficient functioning of the pancreas building up sugar in your body. Glucose then accumulates in your blood and doesn’t reach your cells causing a lot of health problems and diseases that may include:


  • Heart problems
  • Stroke
  • Dental diseases
  • Eye problems
  • Nerve damage
  • Kidney problems


Megagliptin MF helps reduce blood glucose in patients with impaired insulin production, who follow a proper diet and exercise routine.


As directed by your Physician.


As directed by your Physician.

Adverse Reactions/ Side Effects

The following is a list of possible side-effects that may occur from all constituting ingredients of Megagliptin MF ER Tablet. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious. Consult your doctor if you observe any of the following side-effects, especially if they do not go away.


  • Gastrointestinal disturbances
  • Low ph in body tissues and blood
  • Lack or loss of appetite for food
  • Nausea
  • Vomiting
  • Diarrhoea
  • Weight loss
  • Flatulence
  • Altered sense of taste includes metallic taste
  • Rash
  • Malabsorption of vitamin b12
  • Skin reactions
  • Abdominal pain

Warnings and Precautions

Before using Megagliptin MF ER Tablet, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition. Tell your doctor if your condition persists or worsens. Important counselling points are listed below.


  • Blurred vision
  • Diabetic ketoacidosis
  • Do not take this medication if you are allergic to it
  • Pregnant, planning to become pregnant or breastfeeding
  • Symptoms like nausea, vomiting, abdominal pain, fatigue, anorexia and dark urine


Hypersensitivity to Megagliptin MF ER Tablet is a contraindication. In addition, Megagliptin MF ER Tablet should not be used if you have the following conditions:


  • Acute myocardial infarction
  • Cardiovascular collapse
  • Diabetic ketoacidosis
  • Hypersensitivity
  • Renal disease
  • Septicemia

Drug Interactions

If you use other drugs or over the counter products at the same time, the effects of Megagliptin MF ER Tablet may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions. Megagliptin MF ER Tablet may interact with the following drugs and products:


  • Anti-diabetic drugs
  • Furosemide
  • Prednisone
  • Salbutamol or terbutaline



Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.


Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Megagliptin MF ER Tablet.

Mechanism of Action

In response to meal, a hormone called GLP-1 is secreted by cells of the intestine.GLP-1 is rapidly inactivated by an enzyme called DPP4. Teneligliptin binds to DPP4 and inactivates it, allowing GLP-1 to remain active. Active GLP-1 causes the pancreas to increase insulin secretion there by reducing the blood glucose.


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