METHYLCOBAL

Dosage : Capsule, Injection
Contains : Mecobalamin
Category : Nootropics & Neurotonics/Neurotrophics /Vitamins
Uses : Anaemia
Price :

Methylcobal contains Mecobalamin. Methylcobalamin is a cobalamin (MeB12) used in peripheral neuropathy, diabetic neuropathy etc. It is a form of vitamin B12. It is used in treating diseases of vitamin B12 deficiency (such as pernicious anemia), or diseases of effective B12 deficiency, such as vitamin B12 metabolic pathway pathologies. One study suggests that once absorbed, methylcobalamin may be retained in the body better than cyanocobalamin.

 

Methylcobal is product from Wockhardt Limited. Wockhardt is a global pharmaceutical and biotechnology organisation, providing affordable, high-quality medicines for a healthier world. It is India’s leading research-based global healthcare enterprise with relevance in the fields of Pharmaceuticals, Biotechnology and a chain of advanced Super Speciality Hospitals.

 

Wockhardt is a true Indian Multi-National Company with a multi-ethnic workforce of 8600 Wockhardt Associates from 21 different nationalities globally. It has 3 research centres and 12 manufacturing plants, with businesses ranging from the manufacture and marketing of Pharmaceutical and Bio-pharmaceutical formulations, Active Pharmaceutical Ingredients (APIs) and Vaccines.

Vitamin Deficiency

 

Vitamin deficiency anemia is a lack of healthy red blood cells caused when you have lower than normal amounts of certain vitamins. Vitamins linked to vitamin deficiency anemia include folate, vitamin B-12 and vitamin C. Vitamin deficiency anemia can occur if you don’t eat enough foods containing folate, vitamin B-12 or vitamin C, or it can occur if your body has trouble absorbing or processing these vitamins.

 

Signs and symptoms of vitamin deficiency anemia include fatigue, shortness of breath, dizziness, pale or yellowish skin, weight loss and Numbness or tingling in your hands and feet. Vitamin deficiency anemia develops when your body has a shortage of the vitamins needed to produce enough healthy red blood cells. Red blood cells carry oxygen from your lungs throughout your body.

 

Vitamin B-12 deficiency anemia

 

Vitamin B-12 deficiency can result from a diet lacking in vitamin B-12, which is found mainly in meat, eggs and milk.

However, the most common cause of vitamin B-12 deficiency anemia is a lack of a substance called intrinsic factor, which can be caused when your immune system mistakenly attacks the stomach cells that produce this substance. This type of anemia is called pernicious anemia.

Dosage

As directed by your physician.

Administration

As directed by your Physician.

Adverse Reactions/ Side Effects

Oral: Anorexia, nausea, vomiting and diarrhoea.

 

Parenteral: Rash, headache, hot sensation, diaphoresis and pain/induration at IM inj site.

 

Potentially Fatal: Anaphylactoid reactions (parenteral).

Warnings and Precautions

Contraindications

Not contraindicated in pregnancy and lactation.

Drug Interactions

Decreased GI tract absorption with neomycin, aminosalicylic acid, H2-blockers and colchicine. Reduced serum concentrations with oral contraceptives. Reduced effects in anaemia with parenteral chloramphenicol.

Overdosage

Storage

Mechanism of Action

Mecobalamin is the neurologically active form of vitamin B12 and occurs as a water-soluble vitamin in the body. It is a cofactor in the enzyme methionine synthase, which functions to transfer methyl groups for the regeneration of methionine from homocysteine. In anaemia, it increases erythrocyte production by promoting nucleic acid synthesis in the bone marrow and by promoting maturation and division of erythrocytes.

References

https://www.mayoclinic.org/diseases-conditions/vitamin-deficiency-anemia/symptoms-causes/syc-20355025

https://www.mims.com/india/drug/info/methycobal

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