| Dosage | : | Tablet |
| Contains | : | Metoprolol tartrate 50 mg, telmisartan 40 mg |
| Category | : | Beta blockers |
| Uses | : | Treatment of cardio-vascular diseases |
| Price | : |
Metosartan is a medicine used for treating high blood pressure. By lowering the blood pressure, it helps in preventing future heart attack and stroke. Early treatment with this medicine also improves chances of survival in patients of heart attack.
Metosartan is product from Sun Pharmaceutical Industries Limited. Sun pharma is an Indian multinational pharmaceutical company headquartered in Mumbai, Maharashtra, that manufactures and sells pharmaceutical formulations and active pharmaceutical ingredients (APIs) primarily in India and the United States. The company offers formulations in various therapeutic areas, such as cardiology, psychiatry, neurology, gastroenterology and diabetology. It also provides APIs such as warfarin, carbamazepine, etodolac, and clorazepate, as well as anti-cancers, steroids, peptides, sex hormones, and controlled substances.
High blood pressure
High BP is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.
There are two types of high blood pressure.
Primary (essential) hypertension
For most adults, there’s no identifiable cause of high blood pressure. This type of high blood pressure, called primary (essential) hypertension, tends to develop gradually over many years.
Secondary hypertension
Some people have high blood pressure caused by an underlying condition. This type of high blood pressure, called secondary hypertension, tends to appear suddenly and cause higher blood pressure than does primary hypertension. Various conditions and medications can lead to secondary hypertension, including:
- Obstructive sleep apnea
- Kidney problems
- Adrenal gland tumors
Uncontrolled high blood pressure can lead to complications including Heart attack or stroke. High blood pressure can cause hardening and thickening of the arteries (atherosclerosis), which can lead to a heart attack, stroke or other complications.
Aneurysm. Increased blood pressure can cause your blood vessels to weaken and bulge, forming an aneurysm. If an aneurysm ruptures, it can be life-threatening.
Heart failure. To pump blood against the higher pressure in your vessels, the heart has to work harder. This causes the walls of the heart’s pumping chamber to thicken (left ventricular hypertrophy). Eventually, the thickened muscle may have a hard time pumping enough blood to meet your body’s needs, which can lead to heart failure. Also, in some cases, it can lead to vision loss, difficulty in memory and understanding.
Dosage
As directed by your physician.
Administration
As directed by your physician.
Adverse Reactions/ Side Effects
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Warnings and Precautions
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Contraindications
Allergy to constituents of the medicine
- If you are suffering from heart problems like heart block, heart failure or sick sinus syndrome (abnormal heart rhythms)
- If you have a specific type of angina called Prinzmetal’s angina
- If you have reduced blood supply to your limbs (peripheral arterial disease)
- If you have asthma or chronic obstructive pulmonary disease (COPD)
- If you are suffering from adrenal gland tumor (phaeochromocytoma)
- If you have a condition called metabolic acidosis (increased acidity in your body or are on medicines to treat irregular heart rhythm like disopyramide)
- If you have diabetes associated with frequent low blood sugar levels
- If you are suffering from low blood pressure (hypotension)
- If you are in the second or third trimester of pregnancy
- If you have blockage of any duct that carries bile from the liver to gallbladder (obstructive biliary disorders) or severe liver disease
- If you have diabetes and you are on Aliskiren, do not take this medicine
Low blood pressure or giddiness when you stand, Tiredness. Slow heart rate. Dizziness, Headache, Nausea or vomiting, Stomach pain, Shortness of breath, Flu-like symptoms, Diarrhoea, Conjunctivitis (inflammation of eye also known as pink eye), Palpitations (irregular heartbeats), Constipation, Chest pain, Dry Mouth
Drug Interactions
This medicine contains Metoprolol and Telmisartan, any interactions seen with these two components when taken alone may occur with this combination
Do not take it with medicines like Amiodarone, Disopyramide or painkillers like Indomethacin, Sulindac, Diclofenac and Foctafenine as these can decrease the effect of this medicine
If you have diabetes, dose adjustment may be needed as this medicine can cause a drop in blood glucose levels and close glucose monitoring is advised
Medicines used to treat high blood pressure and benign prostatic hyperplasia (Prazosine, Tamsulosin, Terazosin and Doxazosin)
If you have diabetes and you are on Aliskiren, do not take this medicine
Caution is needed if you are taking Fluoxetine, Lithium, Paroxetine, Bupropion, Thioridazine (medicines for psychiatric illness), Diphenhydramine, Hydroxychloroquine and Mefloquine
- Medicines used to treat acidity or ulcers (antacids) like Cimetidine
- Medicines used to treat heart problems (Digoxin)
- Medicines used to treat depression and Parkinson’s disease (Monoamine Oxidase inhibitors)
- Medicines used to lower down the blood pressure (Clonidine, Guanfacine, Moxonidine, Methyldopa and Rilmenidine)
- Medicines used to treat migraine (Ergotamine) or Nitroglycerine
- General anaesthetics or local anesthetic (Lidocaine)
- Medicines that may increase blood potassium levels like salt containing potassium and potassium-sparing diuretics
- Blood thinners like Warfarin and Heparin
- Immunosuppressives (Cyclosporin or Tacrolimus)
- Medicines used to treat infections like Trimethoprim, Rifampicin or Terbinafine
- Medicines known as Diuretics (water pills) used to treat high blood pressure like Furosemide and Hydrochlorothiazide
Food Interactions
It is advised to avoid high potassium-containing foods like spinach, broccoli and potatoes as Telmisartan is known to increase blood potassium levels.
Overdosage
Symptoms of overdose may include low blood pressure, irregular heartbeat, heart failure, shock, loss of consciousness, coma, nausea, vomiting, bluish colour of the lips, tongue and skin, low levels of potassium or calcium in blood, dizziness and kidney failure.
Storage
Store below 25°C
Store it in original packing to protect it from light
Try to keep out of the reach of children
Mechanism of Action
Metoprolol works by slowing the heart rate and relaxing blood vessels and reduces high blood pressure. Angiotensin II is a substance produced in the body which causes the narrowing of blood vessels. It leads to an increase in blood pressure
Telmisartan prevents the binding of Angiotensin II to its receptors and causes the blood vessels to relax and lowers the blood pressure
References
https://www.mims.com/india/drug/info/metosartan/metosartan%20bilayer%20coated%20tab
https://www.1mg.com/drugs/metosartan-50-tablet-er-154227
https://pharmeasy.in/online-medicine-order/metosartan-50mg-strip-of-10-tablets-25568
https://en.wikipedia.org/wiki/Sun_Pharmaceutical
https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/symptoms-causes/syc-20373410
https://www.ndrugs.com/?s=metosartan&t=dosage