Dosage : Injection
Contains : Ceftriaxone 1000 mg and Sulbactam 500 mg
Category : Antibiotic
Uses : Bacterial infections
Price :

Monocef-SB contains Ceftriaxone and Sulbactam. Ceftriaxone is a 3rd Generation Cephalosporin and a wide spectrum antibiotic. Sulbactam is a beta-lactamase inhibitor.


Ceftriaxone interferes with the formation of bacterial cell walls thereby inhibiting its action. But, bacterias secrete enzyme called beta-lactamase that inhibits the activity of ceftriaxone. Sulbactam irreversibly binds to beta-lactamase and blocks it. Hence, it prevents Ceftriaxone from degradation.


Monocef-SB is used and administered in the treatment of both gram -ve and gram +ve bacterial infections. It is used to treat bacterial infections like gonorrhea (infection of female reproductive organ), pelvic inflammatory disease and also infections of lungs, skin, blood, bones, joints and abdomen.


Monocef-SB is a brand from Aristo Pharmaceuticals Pvt. Ltd. Since its inception in 1971, Aristo pharmaceuticals is supporting medical profession in promoting and preserving good health. It is one of the Top 10 pharmaceutical companies of India delivering world class quality products.

Gonorrhea is a sexually transmitted disease (STD). It’s caused by infection with the bacterium Neisseria gonorrhoeae. It tends to infect warm, moist areas of the body, including the:


  • Urethra (the tube that drains urine from the urinary bladder)
  • Eyes
  • Throat
  • Vagina
  • Anus
  • Female reproductive tract (the fallopian tubes, cervix, and uterus)


Gonorrhea passes from person to person through unprotected oral, anal, or vaginal sex. People with numerous sexual partners or those who don’t use a condom are at greatest risk of infection. The best protections against infection are abstinence, monogamy (sex with only one partner), and proper condom usage. Behaviors that make a person more likely to engage in unprotected sex also increase the likelihood of infection. These behaviors include alcohol abuse and illegal drug abuse, particularly intravenous drug use.


Pelvic inflammatory disease (PID) is an infection of the female reproductive organs. The pelvis is in the lower abdomen and includes the fallopian tubes, ovaries, cervix, and the uterus.


Several different types of bacteria can cause PID, including the same bacteria that cause the sexually transmitted infections (STIs) gonorrhea and chlamydia. What commonly occurs is that bacteria first enter the vagina and cause an infection. As time passes, this infection can move into the pelvic organs.


PID can become extremely dangerous, even life-threatening, if the infection spreads to your blood. If you suspect that you may have an infection, see your doctor as soon as possible.


As directed by your Physician.


As directed by your Physician.

Adverse Reactions/ Side Effects

The following is a list of possible side-effects that may occur from all constituting ingredients of Monocef SB Injection. This is not a comprehensive list. These side-effects are possible, but do not always occur. Some of the side-effects may be rare but serious.


Consult your doctor if you observe any of the following side-effects, especially if they do not go away.


  • Pain at site of injection
  • Rash
  • Itch
  • Injection site reactions
  • Itchiness
  • Fever
  • Leukopenia
  • Diarrhea
  • Nausea
  • Headache
  • Monocef SB Injection may also cause side-effects not listed here.

Warnings and Precautions

Before using Monocef SB Injection, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.). Some health conditions may make you more susceptible to the side-effects of the drug. Take as directed by your doctor or follow the direction printed on the product insert. Dosage is based on your condition.


Tell your doctor if your condition persists or worsens. Important counseling points are listed below.


  • Gallbladder disease
  • Gastrointestinal disease
  • Hypersensitivity to penicillins
  • If you develop bloody or watery diarrhea contact your doctor immedately
  • Infants
  • Inform your doctor if you have had allergic reactions to penicillins or other cephalosporins in the past
  • It is important that you finish the entire course as prescribed
  • Liver and kidney problems
  • Malnutrition

Pregnant, planning to get pregnant or breastfeeding


Hypersensitivity to Monocef SB Injection is a contraindication. In addition, Monocef -SB Injection should not be used if you have the following conditions:


  • Asthma
  • Clostridium difficile bacterial infection
  • Diabetes
  • Hyperbilirubinemic infants
  • Hypersensitivity
  • Hypersensitivity to cephalosporins
  • Kidney or gastrointestinal disease
  • Neonates requiring IV solutions that contain calcium
  • Pseudomembranous colitis

Runny nose due to allergy

Drug Interactions

If you use other drugs or over the counter products at the same time, the effects of Monocef SB Injection may change. This may increase your risk for side-effects or cause your drug not to work properly. Tell your doctor about all the drugs, vitamins, and herbal supplements you are using, so that you doctor can help you prevent or manage drug interactions.


Monocef SB Injection may interact with the following drugs and products:


  • Allopurinol
  • Calcium
  • Chloramphenicol
  • Probenecid
  • Tetracyclines



Store medicines at room temperature, away from heat and direct light. Do not freeze medicines unless required by package insert. Keep medicines away from children and pets.

Do not flush medications down the toilet or pour them into drainage unless instructed to do so. Medication discarded in this manner may contaminate the environment. Please consult your pharmacist or doctor for more details on how to safely discard Monocef-SB Injection.

Mechanism of Action


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