MONTAZ

Dosage : Injection
Contains : Ceftriaxone 500g + Tazobactam 62.5 mg, + Tazobactam 125 mG
Category : Antibiotic
Uses : Bacterial infections
Price :

Montaz contains Ceftriaxone and Tazobactam. Ceftriaxone is a 3rd Generation Cephalosporin and a wide spectrum antibiotic. Tazobactam is a beta-lactamase inhibitor.

Ceftriaxone interferes with the formation of bacterial cell walls thereby inhibiting its action. But, bacterias secrete enzyme called beta-lactamase that curbs the activity of ceftriaxone. Sulbactam irreversibly binds to beta-lactamase and blocks it. Hence, it prevents Ceftriaxone from degradation.

 

Montaz is used and administered in the treatment of both gram -ve and gram +ve bacterial infections. It is used to treat bacterial infections like:

 

  • Bacterial meningitis
  • Bone and joint infections
  • Community-acquired pneumonia
  • Intra-abdominal infections
  • Lower respiratory tract infections
  • Pelvic inflammatory disease
  • Uncomplicated gonorrhoea
  • Skin and skin structure infections
  • Bacterial septicaemia
  • Urinary tract infections

 

Montaz is a brand from Aristo Pharmaceuticals Pvt. Ltd. Since its inception in 1971, Aristo pharmaceuticals is supporting medical profession in promoting and preserving good health. It is one of the Top 10 pharmaceutical companies of India delivering world class quality products.

This antibiotic is used for a variety of severe bacterial infections. Some of them are explained below-

 

Pneumonia

 

Pnemonia is an infection that inflames the air sacs in one or both lungs. The air sacs may fill with fluid or pus (purulent material), causing cough with phlegm or pus, fever, chills, and difficulty breathing

 

Hospital-acquired pneumonia

 

Some people catch pneumonia during a hospital stay for another illness. Hospital-acquired pneumonia can be serious because the bacteria causing it may be more resistant to antibiotics and because the people who get it are already sick. People who are on breathing machines (ventilators), often used in intensive care units, are at higher risk of this type of pneumonia.

 

Septicemia

 

Septicemia is a life-threatening complication of an infection. Sepsis occurs when chemicals released in the bloodstream to fight an infection trigger inflammation throughout the body. This can cause a cascade of changes that damage multiple organ systems, leading them to fail, sometimes even resulting in death.

Dosage

As directed by your Physician.

Administration

As directed by your Physician

Adverse Reactions/ Side Effects

Superinfection; anaphylaxis; diarrhoea; local reactions; blood dyscrasias; rash, fever, pruritus; elevated transaminases and alkaline phosphatase. GI effects; pseudomembranous colitis; hematologic effects; hypersensitivity reactions; CNS disturbances; hypertension; chest pain; edema; moniliasis; rhinitis; dyspnea; hypotension; ileus; syncope; local Inj site reactions; rigors. Potentially Fatal: Pseudomembranous colitis; nephrotoxicity.

Warnings and Precautions

History of penicillin allergy; lactation. Consider possibility of pseudomembranous colitis in patients who present with diarrhoea subsequent to the admin of antibacterial agents. Monitor prothrombin time in patients with impaired vit K synthesis or low vit K stores during treatment. Prolonged treatment may result in overgrowth of nonsusceptible organisms. Caution in patients with a history of GI disease, especially colitis. Discontinue treatment in patients who develop signs/symptoms suggestive of gallbladder disease. Not to be used in hyperbilirubinemic neonates, especially prematures.

Contraindications

Hypersensitivity to cephalosporins and β-lactamase inhibitors.

Drug Interactions

Probenecid; aminoglycosides; vecuronium, methotrexate; oral anticoagulants; heparin.

 

Potentially Fatal: Disulfiram-like reaction with alcohol. Nephrotoxicity with aminoglycosides and furosemide.

Overdosage

Symptomatic and supportive treatment should be initiated.

Storage

–

Mechanism of Action

Ceftriaxone interferes with the biosynthesis of the peptidoglycan component of the bacterial cell way by binding to and inactivating penicllin-binding proteins (PBPs). Tazobactam is a penicillanic acid sulfone derivative with β-lactamase inhibitory properties. It enhances the activity of β-lactam antibacterials against β-lactamase-producing bacteria.

References

https://www.mims.com/india/drug/info/ceftriaxone%20%2b%20tazobactam/?type=full&mtype=generic#Indications

https://www.mayoclinic.org/diseases-conditions/urinary-tract-infection/symptoms-causes/syc-20353447

https://www.mayoclinic.org/diseases-conditions/sore-throat/symptoms-causes/syc-20351635

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