MONTICOPE

Dosage : Tablet
Contains : Montelukast 10 mg + Levocetirizine dihydrochloride 5 mg
Category : Antihistamines & Antiallergics
Uses : Allergies
Price :

Monticope tablet is a combination drug containing Montelukast and Levocetirizine dihydrochloride. Montelukast belongs to class of drugs called selective leukotriene receptor antagonist. It inhibits the effects of chemical called cysteinyl leukotrienes in the airway. Cysteinyl leukotrienes is associated with airway oedema, smooth muscle contraction and inflammation.

 

Levocetirizine is an antihistamine. Histamine is a chemical that is released in body when a person having allergy comes in contact with the allergy trigger like pollen, ragweed, pet dander, or dust mites, etc. Histamine leads to swelling of the tissue in nose making it stuffy, running nose and eyes, sometimes mouth to itch. It can also lead to itchy rash on skin, called hives.

 

Monticope is indicated for relief of following symptoms of allergic rhinitis:

 

  • Runny nose and nasal congestion
  • Watery, itchy, red eyes (allergic conjunctivitis)
  • Sneezing
  • Cough
  • Itchy nose, roof of mouth or throat
  • Swollen, blue-colored skin under the eyes (allergic shiners)
  • Postnasal drips
  • Fatigue

 

Monticope is a product from Mankind Pharma. Mankind Pharma came into existence in 1986 and became a fully-integrated pharma company in 1995. It is one of the leading Indian pharma companies with over 14000 employees and presence in 34 countries and it strive to provide world-class medications at affordable prices.

Allergic symptoms are caused by your immune system due to various allergens that may trigger an allergic reaction. Allergies are dependent on your genes and can vary from person to person.

 

Allergic reactions happen when the immune system recognises an allergen and the cells release histamines which causes inflammation in that region. This prompts the immune system to respond to the inflammation and start deep repair.

 

Patients could be allergic to anything ranging from pollens, nuts, fur to even dairy products. Allegra can be used to treat allergic symptoms that may include: Tearing, Running nose, Itchy eyes, Sneezing, Redness of the eye, Hives

Dosage

As directed by your Physician.

Administration

As directed by your Physician.

Adverse Reactions/ Side Effects

Significant: Behavioural changes (e.g. agitation, anxiety, depression, dream abnormalities, obsessive-compulsive disorder).

 

Ear and labyrinth disorders: Otalgia, otitis media. Eye disorders: Myopia, conjunctivitis. Gastrointestinal disorders: Diarrhoea, nausea, vomiting, abdominal pain, dyspepsia, gastroenteritis. General disorders and administration site conditions: Pyrexia. Infections and infestations: Viral infection, tooth infection.

 

Nervous system disorders: Headache, drowsiness, dizziness. Respiratory, thoracic and mediastinal disorders: Upper respiratory tract infection, cough, acute bronchitis, influenza, laryngitis, pharyngitis, rhinorrhoea, sinusitis, sinus headache, pneumonia. Skin and subcutaneous tissue disorders: Rash, eczema or atopic dermatitis, skin infection, urticaria. Vascular disorders: Epistaxis.

Warnings and Precautions

Aspirin-sensitive asthmatic patient must continue avoiding aspirin and other NSAIDs. Not intended for treatment of acute asthma attacks. Not recommended as monotherapy in treatment of moderate chronic asthma. Avoid abrupt substitution to oral or inhaled corticosteroids. Children. Pregnancy and lactation. Patient Counselling -This drug may cause dizziness or drowsiness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor for signs and symptoms of behavioural changes.

Contraindications

Drug Interactions

Decreased plasma concentration with CYP450 inducers (e.g. phenytoin, phenobarbital, rifampicin). Gemfibrozil may increase montelukast serum concentration.

Overdosage

Symptoms: Abdominal pain, somnolence, thirst, headache, vomiting, psychomotor hyperactivity.

 

Management: Supportive treatment.

Storage

Oral: Store below 30°C. Protect from light and moisture.

Mechanism of Action

Montelukast is a selective leukotriene receptor antagonist with a long duration of action. It inhibits cysteinyl leukotriene type-1 (CysLT1) receptor found in the human airway and on pro-inflammatory cells. The binding of CysLTs in leukotriene receptors are involved in the pathophysiology of asthma, including smooth muscle contraction, airway oedema and inflammation; CysLTs are released from the nasal mucosa after allergen exposure which is associated with symptoms of allergic rhinitis.

References

http://cimsasia.com/india/drug/info/montelukast/?type=full&mtype=generic#Actions

https://www.mayoclinic.org/diseases-conditions/hay-fever/symptoms-causes/syc-20373039

https://www.mims.com/india/drug/info/monticopehttps://www.ndrugs.com/?s=monticope&t=dosage

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