MOX

Dosage : Capsule, Dry syrup, Powder for injection
Contains : Amoxicillin 500 mg
Category : Penicillins
Uses : Bacterial infections
Price :

Mox contains the semi synthetic antibiotic Amoxicillin with a bactericidal effect. It binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the process necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis killing the bacteria.

 

Mox is available as 250 mg and 500 mg capsules and also as a dry syrup for kids.

 

Mox is prescribed in following conditions:

 

  • Pharyngitis
  • Tonsillitis
  • Pneumonia
  • Bronchitis
  • Severe or recurrent respiratory tract infections
  • Typhoid and paratyphoid fever
  • Urinary tract infections
  • Dental abscess
  • Biliary tract infections
  • Endocarditis
  • Gonorrhoea
  • Otitis media
  • Actinomycosis
  • Gastroenteritis
  • Mouth infections
  • Spleen disorders
  • Prophylaxis of endocarditis
  • pylori infection

 

Mox is brand from Sun Pharmaceuticals. Established in 1983, Sun Pharmaceuticals has more than 40 manufacturing units with world-class quality in design, equipment and operations in all manufacturing facilities across 6 continents.

Bacterial infections cause a variety of disease. Some of them are listed below-

 

Respiratory tract infections (RTIs)

 

RTI can affect the sinuses, throat, airways or lungs. Symptoms of an RTI include:

a cough – you may bring up mucus (phlegm), sneezing, a stuffy or runny nose or sore throat. RTIs are often spread in the coughs and sneezes of someone with an infection.

 

There are several different types. They’re usually grouped into upper and lower RTIs.

 

Upper RTIs (sinuses and throat)        Lower RTIs (airways and lungs)

 

Common cold                                                Bronchitis

Sinusitis (sinus infection)                            Bronchiolitis

Tonsillitis                                                       Chest infection

Laryngitis                                                       Pneumonia (lung infection)

 

Flu can be an upper or lower RTI. Lower RTIs tend to last longer and can be more serious.

 

Endocarditis

 

Endocarditis is an infection of the endocardium, which is the inner lining of your heart chambers and heart valves.

Endocarditis generally occurs when bacteria from another part of your body, such as your mouth, spread through your bloodstream and attach to damaged areas in your heart. If it’s not treated quickly, endocarditis can damage or destroy your heart valves and can lead to life-threatening complications. Treatments for endocarditis include antibiotics and, in certain cases, surgery.

Dosage

As directed by your Physician.

Administration

As directed by your Physician.

Adverse Reactions/ Side Effects

Hyperactivity, agitation, insomnia, dizziness; maculopapular rash, exfoliative dermatitis, urticaria, hypersensitivity vasculitis; diarrhoea, nausea, vomiting; anaemia, thrombocytopenia, leucopenia, agranulocytosis.

Potentially Fatal: Neuromuscular hypersensitivity; pseudomembranous colitis.

Warnings and Precautions

Monitor

Periodically assess renal, hepatic, and hematopoietic function during prolonged therapy. Patients diagnosed with gonorrhea should have a serologic test for syphilis at the time of treatment and a follow-up serologic test after 3 months. In the treatment of UTI, frequent bacteriological and clinical appraisals are necessary.

 

Special Precautions:

 

Renal and hepatic disease; pregnancy, lactation; infectious mononucleosis.

Contraindications

  • Caution when used during pregnancy
  • Caution when used during lactation
  • Hypersensitivity

Drug Interactions

Increased levels with disulfiram and probenecid. Decreased effects with tetracyclines and chloramphenicol.

Potentially Fatal: Increase effects of oral anticoagulants.

Overdosage

–

Storage

–

Mechanism of Action

Amoxicillin inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall by binding to one or more of the penicillin-binding proteins (PBPs), thus inhibiting cell wall biosynthesis resulting in bacterial lysis.

References

https://www.mayoclinic.org/diseases-conditions/endocarditis/symptoms-causes/syc-20352576

https://www.nhs.uk/conditions/respiratory-tract-infection/

https://pubchem.ncbi.nlm.nih.gov/compound/33613#section=Top

http://www.mims.com/india/drug/info/mox

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