| Dosage | : | Syrup |
| Contains | : | Peptone 0.322 mg, manganese chloride 6.67 mg/15 mL |
| Category | : | Appetite Enhancers |
| Uses | : | Anorexia, sluggish digestion |
| Price | : |
Neogadine elixir syrup contains Iodised Peptone and Manganese Chloride. Iodised Peptone helps to improve the development of digestive enzymes while Manganese Chloride boosts production of starch-digesting enzymes. The Neogadine syrup works by treating irritation in the digestive system and soothing nerves to improve the digestion. They increase the secretion of the salivary and gastric glands, sharpens appetite and promotes digestion. It also helps in emptying of stomach by relieving constipation and flatulence.
The syrup proves beneficial in conditions like lack of appetite and loss of weight.
Neogadine is product from Raptakos, Brett & Co. Ltd. It was established in 1930.
Research is focused primarily in the areas of nutrition and dietetics, APIs, pharmaceutical dosage forms and analytical methods. Other pharmaceutical products cover several therapeutic groups such as Vitamin and Mineral supplements, Haematinics, gastrointestinals, digestive enzymes, NSAIDs and various other therapeutic categories.
Cyanocobalamin is vital to growth, hematopoiesis and nucleoprotein and myelin synthesis. As a hematopoietic agent, it is converted to coenzyme B12 needed in the conversion of methylmalonate to succinate and production of methionine from homocysteine, a reaction requiring folate. In the absence of folate, such metabolites cannot be formed and folate deficiency occurs. It is also involved in the maintenance of reduced sulfhydryl (SH) groups which are required by various SH-activated enzyme systems. Through such processes, cyanocobalamin participates in fat and carbohydrate metabolism as well as protein synthesis.
Anorexia
Anorexia nervosa — often simply called anorexia — is an eating disorder characterized by an abnormally low body weight, an intense fear of gaining weight and a distorted perception of weight. People with anorexia place a high value on controlling their weight and shape, using extreme efforts that tend to significantly interfere with their lives.
To prevent weight gain or to continue losing weight, people with anorexia usually severely restrict the amount of food they eat. They may control calorie intake by vomiting after eating or by misusing laxatives, diet aids, diuretics or enemas. They may also try to lose weight by exercising excessively. No matter how much weight is lost, the person continues to fear weight gain.
Dosage
As directed by your Physician.
Administration
As directed by your Physician.
Adverse Reactions/ Side Effects
Monitor
Obtain all hematologic parameters, including hemacrit, reticulocyte count, and vitamin B 12, folate, and iron levels, at the beginning of vitamin B 12 treatment. Monitor serum potassium levels during therapy.
Periodically monitor serum B 12 levels to establish adequacy of therapy. Monitor vitamin B 12 concentrations and CBC 1 month after starting treatment and at 3- to 6-months intervals thereafter. Patients with declining or abnormally low vitamin B 12 concentrations despite maximal doses of intranasal treatment should be switched to IM vitamin B 12 .
Warnings
Fetal harm: Continuous administration of Neogadine (Magnesium Chloride) sulfate beyond 5 to 7 days to pregnant women can lead to hypocalcemia and bone abnormalities in the developing fetus. These bone abnormalities include skeletal demineralization and osteopenia. In addition, cases of neonatal fracture have been reported. The shortest duration of treatment that can lead to fetal harm is not known. Neogadine (Magnesium Chloride) sulfate should be used during pregnancy only if clearly needed. If Neogadine (Magnesium Chloride) sulfate is given for treatment of preterm labor, the woman should be informed that the efficacy and safety of such use have not been established and that use of Neogadine (Magnesium Chloride) sulfate beyond 5 to 7 days may cause fetal abnormalities.
Aluminum toxicity: This product contains aluminum that may be toxic. Aluminum may reach toxic levels with prolonged parenteral administration if kidney function is impaired. Premature neonates are particularly at risk because their kidneys are immature, and they require large amounts of calcium and phosphate solutions, which contain aluminum.
Parenteral use in the presence of renal insufficiency may lead to Neogadine (Magnesium Chloride) intoxication. Intravenous use in the eclampsia should be reserved for immediate control of life-threatening convulsions.
Warnings and Precautions
The adverse effects of parenterally administered Neogadine (Magnesium Chloride) usually are the result of Neogadine (Magnesium Chloride) intoxication. These include flushing, sweating, hypotension, depressed reflexes, flaccid paralysis, hypothermia, circulatory collapse, cardiac and central nervous system depression proceeding to respiratory paralysis. Hypocalcemia with signs of tetany secondary to Neogadine (Magnesium Chloride) sulfate therapy for eclampsia has been reported.
Contraindications
Caution when used during pregnancy
Caution when used during lactation
Cyanocobalamin and Geriatic- Use with caution, usually starting at the low end of the dosage range, because of the greater frequency of decreased hepatic, renal, or cardiac function, and concomitant diseases or other drug therapy.
Drug Interactions
CNS Depressants – When barbiturates, narcotics or other hypnotics (or systemic anesthetics), or other CNS depressants are to be given in conjunction with Neogadine (Magnesium Chloride), their dosage should be adjusted with caution because of additive CNS depressant effects of Neogadine (Magnesium Chloride). CNS depression and peripheral transmission defects produced by Neogadine (Magnesium Chloride) may be antagonized by calcium.
Neuromuscular Blocking Agents – Excessive neuromuscular block has occurred in patients receiving parenteral Neogadine (Magnesium Chloride) sulfate and a neuromuscular blocking agent; these drugs should be administered concomitantly with caution.
Cardiac Glycosides – Neogadine (Magnesium Chloride) sulfate should be administered with extreme caution in digitalized patients, because serious changes in cardiac conduction which can result in heart block may occur if administration of calcium is required to treat Neogadine (Magnesium Chloride) toxicity.
Overdosage
Neogadine (Magnesium Chloride) intoxication is manifested by a sharp drop in blood pressure and respiratory paralysis. Disappearance of the patellar reflex is a useful clinical sign to detect the onset of Neogadine (Magnesium Chloride) intoxication. In the event of overdosage, artificial ventilation must be provided until a calcium salt can be injected intravenously to antagonize the effects of Neogadine (Magnesium Chloride).
Storage
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Mechanism of Action
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References
http://www.drugsupdate.com/brand/generic/Cyanocobalamin/23359/8
https://www.1mg.com/otc/neogadine-drop-otc258192
https://www.sdrugs.com/?c=drug&s=neogadine
https://www.mayoclinic.org/diseases-conditions/anorexia-nervosa/symptoms-causes/syc-20353591