Ferrous fumarate: Fe chelates w/ tetracyclines, absorption of both agents may be impaired; it also chelates w/ acetohydroxamic acid, reducing the absorption of both. Reduced absorption w/ antacids and PPIs, neomycin, cholestyramine, Ca, oral Mg salts and other mineral supplements, Zn and trientine. May form insoluble complexes w/ bicarbonates, carbonates, oxalates, or phosphates, thus absorption is reduced. Increased absorption w/ ascorbic or citric acid.
Chloramphenicol delays plasma clearance and incorporation of Fe into red blood cells by interfering w/ erythropoiesis. Reduces the hypotensive effect of methyldopa. May form toxic complexes w/ dimercaprol. Reduces the absorption of fluoroquinolones, levodopa, carbidopa, entacapone, bisphosphonates, penicillamine, thyroid hormones, mycophenolate, cefdinir and Zn. May reduce the absorption of eltrombopag (give at least 4 hr apart). Folic acid: May reduce serum levels of anticonvulsants (e.g. phenobarbital, phenytoin, primidone). Reduced absorption w/ sulfasalazine. May interfere w/ the action of raltitrexed
Food Interaction
Reduced absorption w/ food esp tea, coffee, cereals, eggs and milk