Paraxin is an effective medicine used for the treatment of serious infections caused by bacteria when other medicines are ineffective or are unable to give the desired results.
Paraxin is product from Abbott Laboratories. Abbott is an American multinational medical devices and health care company with headquarters in the Abbott Park Business Center in Lake Bluff, Illinois, United States. The company was founded by Chicago physician Wallace Calvin Abbott in 1888 to formulate known drugs; today, it sells medical devices, diagnostics, branded generic medicines and nutritional products. It split off the research-based pharmaceuticals into AbbVie in 2013.
Among its well-known products across the medical devices, diagnostics, and nutrition product divisions are Pedialyte, Similac, Ensure, Glucerna, ZonePerfect, FreeStyle Libre, i-STAT and MitraClip.
Bacterial Infections – Infections caused by Bacteria can affect gynaecological systems, skin, ear and eye which can be treated by Paraxin.
Vulvovaginitis is an inflammation or infection of the vulva and vagina. It’s a common condition that affects women and girls of all ages. It has a variety of causes. Other names for this condition are vulvitis and vaginitis.
A bacterial infection can cause a greyish-white discharge with a fishy odor.
An ear infection occurs when a bacterial or viral infection affects the middle ear — the sections of your ear just behind the eardrum. Ear infections can be painful because of inflammation and fluid build up in the middle ear.
Ear infections can be chronic or acute. Acute ear infections are painful but short in duration. Chronic ear infections either don’t clear up or recur many times. Chronic ear infections can cause permanent damage to the middle and inner ear.
Avoid prolonged use. Not indicated for treatment of viral infections or for prophylaxis of bacterial infections. Renal and hepatic impairment. Children. Pregnancy and lactation (ophthalmic, otic). Patient Counselling Eye drops may cause transient blurred vision, if affected do not drive or operate machinery. Monitoring Parameters Monitor chloramphenicol plasma concentration, hepatic and renal functions periodically. Check CBC with differential at baseline and every 2 days during treatment. Perform culture and susceptibility tests; consult local recommendations before treatment initiation due to antibiotic resistance risks.
Hypersensitivity. Known or family history of blood dyscrasias (e.g. aplastic anaemia), acute porphyria, active immunisation. Perforated eardrum (otic). Pregnancy and lactation (oral, IV). Concomitant administration of drugs that cause bone marrow depression.
Enhances the effects of coumarin anticoagulants (e.g. dicoumarol, warfarin), certain hypoglycaemics (e.g. chlorpropamide, tolbutamide) and antiepileptics (e.g. phenytoin). Hepatic enzyme inducers (e.g. phenobarbital, rifampicin) may decrease chloramphenicol plasma concentrations. May decrease the effects of Fe and vit B12 in anaemic patients. Prolonged treatment may reduce the efficacy of oestrogen-containing oral contraceptives. May increase the plasma levels of calcineurin inhibitors (e.g. tacrolimus, ciclosporin).
Potentially Fatal: Increased haematologic toxicity with drugs that cause bone marrow depression (e.g. cytotoxic agents, sulfonamides).
Symptoms: IV: Aplastic anaemia, thrombocytopenia, leucopenia, increased Fe levels, nausea, vomiting, diarrhoea. Management: IV: Consider charcoal haemoperfusion to remove chloramphenicol from plasma.
Intravenous: IV inj: Store below 25°C. Protect from light. Reconstituted IV inj: Store between 2-8°C; stable for 24 hours. Ophthalmic: Eye drops solution: Store between 2-8°C. Do not freeze. Protect from light. Eye ointment: Store below 25°C. Protect from light. Oral: Store below 25°C. Protect from light. Otic/Aural: Ear drops solution: Store between 2-8°C. Do not freeze. Protect from light.
Mechanism of Action
Chloramphenicol inhibits bacterial protein synthesis by binding to 50S subunit of the bacterial ribosome, thus preventing amino acid transfer to growing peptide chains thereby inhibiting protein synthesis.