Rablet

Dosage : Tablet and Vial
Contains : Rabeprazole
Category : Antacids
Uses : Peptic ulcers
Price :

Rablet Capsule is a drug used in the treatment of stomach ulcers, Gastroesophageal reflux disease (GERD) and other acidity related disorders by decreasing the acid produced in the stomach.

 

Rablet-D contains Rabeprazole. Rablet is an antiulcer drug in the class of proton pump inhibitors.

 

Rablet is product from Lupin. Lupin Limited, headquartered in Mumbai, India, is strongly research focused. The company has a state-of-the-art R&D center in Pune and is a leading global player in Anti-TB, Cephalosporins (anti-infectives) and Cardiovascular drugs (ACE-inhibitors and cholesterol reducing agents) and has a notable presence in the areas of diabetes, anti-inflammatory and respiratory therapy.

GERD

 

Gastroesophageal reflux disease (GERD) occurs when stomach acid frequently flows back into the tube connecting your mouth and stomach (esophagus). This backwash (acid reflux) can irritate the lining of your esophagus. Many people experience acid reflux from time to time. GERD is mild acid reflux that occurs at least twice a week, or moderate to severe acid reflux that occurs at least once a week.

Dosage

As directed by your Physician

Administration

As directed by your Physician

Adverse Reactions/ Side Effects

Significant: New-onset or exacerbation of subacute cutaneous and systemic lupus erythematosus, osteoporosis-related bone fractures, fundic gland polyps, acute interstitial nephritis, Clostridium difficile-associated diarrhoea (hospitalised patients). Rarely, hypomagnesaemia, vitamin B12 deficiency.

 

Gastrointestinal disorders: Diarrhoea, vomiting, nausea, abdominal pain, constipation, flatulence. General disorders and administration site conditions: Back pain, asthenia, influenza-like illness. Hepatobiliary disorders: Hepatic encephalopathy, hepatitis. Infections and infestations: Infection (e.g. Salmonella, Campylobacter).

 

Investigations: Increased liver enzymes. Nervous system disorders: Headache, dizziness.

Psychiatric disorders: Insomnia. Respiratory, thoracic and mediastinal disorders: Cough, pharyngitis, rhinitis.

Warnings and Precautions

Patients at risk of osteoporosis, reduced body stores or with risk factors for vitamin B12 malabsorption,

 

PPI-induced autoimmune disease. Severe hepatic impairment. Children and elderly. Pregnancy and lactation.

 

Patient Counselling This drug may cause somnolence, if affected, do not drive or operate machinery.

 

Monitoring Parameters Monitor magnesium levels prior to initiation of therapy and periodically thereafter on long-term treatments or in patients taking digoxin, diuretics or other drugs that cause hypomagnesaemia.

Contraindications

Hypersensitivity

 

Pregnancy- Caution when used during pregnancy. Category B Drug
Children- Safety and efficacy not established in the short-term treatment of GERD in children younger than 12 yr of age.

Drug Interactions

May reduce absorption of ketoconazole and itraconazole. May prolong the elimination of diazepam, phenytoin and warfarin.

Overdosage

–

Storage

–

Mechanism of Action

Rabeprazole is a PPI that suppresses gastric acid secretion by inhibiting the gastric H+/K+ ATPase at the secretory surface of the gastric parietal cell.

References

https://www.mayoclinic.org/diseases-conditions/gerd/symptoms-causes/syc-20361940

http://www.drugsupdate.com/brand/generic/RabepRabletle/12017

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