Significant: Hypersensitivity (rash, urticaria, angioedema, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis), diarrhoea, seizures (in patient with renal impairment), acute intravascular haemolysis, elevated INR.
Blood and lymphatic system disorders: Eosinophilia, neutropenia, thrombocytopenia, haemolytic anaemia. Gastrointestinal disorders: Dyspepsia, abdominal pain, gastritis, nausea, vomiting. General disorders and administration site conditions: Fatigue, fever. Hepatobiliary disorders: Rarely, transient hepatitis, cholestatic jaundice. Investigations: Slightly elevated AST and ALT.
Musculoskeletal and connective tissue disorders: Arthralgia, arthritis. Nervous system disorders: Headache, dizziness. Psychiatric disorders: Agitation, confusion, hallucinations, nervousness, hyperactivity. Renal and urinary disorders: Interstitial nephritis (reversible). Reproductive system and breast disorders: Genital and anal pruritus, vaginitis, genital moniliasis and candidiasis, vaginal discharge.
Potentially Fatal: Anaphylaxis, Clostridium difficile-associated diarrhoea (CDAD).