Tazomac contains Piperacillin + Tazobactam. Piperacillin/Tazobactam is a combination antibiotic containing the extended-spectrum penicillin antibiotic piperacillin and the β-lactamase inhibitor tazobactam. Piperacillin has an antimicrobial activity against a wide range of gm-ve organisms including K. pneumoniae, P. aeruginosa, Enterobacteriaceae and against gm+ve organisms eg E. faecalis and B. fragilis. Tazobactam is a penicillanic acid sulfone derivative with beta-lactamase inhibitory properties. In combination, tazobactam enhances the activity of piperacillin against beta-lactamase-producing bacteria. Tazomac 4.5 Injection is a combination medicine used to treat a variety of conditions such as urinary tract infections, lower respiratory tract infections, intra-abdominal infections, skin and skin structure infections, etc. caused by susceptible bacteria.
Tazomac is a product from Macleods. Macleods with its experience spanning more than two decades has emerged as a force to reckon with in global pharmaceutical market. With an asset of more than 10,000 professionally qualified employees across the globe, Macleods is a multiple location organization, is based out of Mumbai, India. It has expertise in range of formulations ranging from tablets to sterile dosage form and from inhalation to novel drug delivery system.
Lower Respiratory tract infections (RTIs)
RTI can affect the sinuses, throat, airways or lungs. Symptoms of an RTI include:
a cough – you may bring up mucus (phlegm), sneezing, a stuffy or runny nose or sore throat. RTIs are often spread in the coughs and sneezes of someone with an infection. Lower RTI includes Bronchitis, Bronchiolitis, chest infection and Pneumonias.
Urinary tract infection (UTI)
UTI is an infection in any part of your urinary system, your kidneys, ureters, bladder and urethra. Most infections involve the lower urinary tract, the bladder and the urethra. Urinary tract infections typically occur when bacteria enter the urinary tract through the urethra and begin to multiply in the bladder. Complications of a UTI may include recurrent infections, especially in women who experience two or more UTIs in a six-month period or four or more within a year. Permanent kidney damage from an acute or chronic kidney infection (pyelonephritis) due to an untreated UTI. Increased risk in pregnant women of delivering low birth weight or premature infants.
Appendicitis is an inflammation of the appendix, a finger-shaped pouch that projects from your colon on the lower right side of your abdomen. Appendicitis causes pain in your lower right abdomen. However, in most people, pain begins around the navel and then moves. As inflammation worsens, appendicitis pain typically increases and eventually becomes severe.
Although anyone can develop appendicitis, most often it occurs in people between the ages of 10 and 30. Standard treatment is surgical removal of the appendix.
Pelvic inflammatory disease (PID)
PID is an infection of the female reproductive organs. It usually occurs when sexually transmitted bacteria spread from your vagina to your uterus, fallopian tubes or ovaries. Signs and symptoms of pelvic inflammatory disease might include Pain in your lower abdomen and pelvis, Heavy vaginal discharge with an unpleasant odour and Abnormal uterine bleeding, especially during or after intercourse, or between menstrual cycles.
As directed by your Physician.
As directed by your Physician.
Adverse Reactions/ Side Effects
Diarrhoea, skin rashes, occasionally platelet mediated bleeding, rigors, malaise, ulcerative stomatitis. Inj-site reactions such as pain, erythema, induration and thrombophlebitis.
Pregnancy and lactation, pseudomembranous colitis. Assess hematopoietic function periodically. Perform periodic electrolyte determinations in patients with low K reserves. Increased risk of fever and rash in patients with cystic fibrosis. Increased risk of bleeding manifestations. Prolonged treatment may increase risk of superinfections. Convulsions or neuromuscular excitability may occur when high doses are used, especially in renally impaired patients. Renal impairment.
Hypersensitivity to any of the antibiotic present. Caution when used during pregnancy
Probenecid prolongs half lives of piperacillin and tazobactam. Increased risk of methotrexate toxicity when used together.
Potentially Fatal: Interacts with heparin and other oral anticoagulants. Prolongs the neuromuscular blockade of vecuronium and non-depolarizing muscle relaxants.
Mechanism of Action
Piperacillin kills bacteria by inhibiting the synthesis of bacterial cell walls. It binds preferentially to specific penicillin-binding proteins (PBPs) located inside bacterial cell walls. Tazobactam works by preventing bacteria from destroying piperacillin.