Injection:
Ototoxicity; increased AST, ALT and serum bilirubin; decreased serum Ca, Mg, Na and K; anaemia, granulocytopenia, thrombocytopenia, leucopenia, leucocytosis and eosinophilia; fever, rash, itching, urticaria, nausea, vomiting, diarrhoea, headache, lethargy, pain on inj site, mental confusion, disorientation. Inhalation: Voice disorder, cough, pulmonary disease, reduced forced expiratory vol, sputum discolouration, rales, dyspnoea, oropharyngeal pain, haemoptysis, pharyngolaryngeal pain, fever, chest discomfort, malaise, skin rash, increased serum glucose, nausea, dysgeusia, vomiting, diarrhoea, xerostomia, increased erythrocyte sedimentation rate, increased serum Ig, myalgia, hypoacusis, deafness. Ophth oint/soln: Localized ocular toxicity and hypersensitivity (e.g. itching and oedema of the eyelid), conjunctival erythema, punctate keratitis, increased lacrimation.
Potentially Fatal:
Neurotoxicity and nephrotoxicity; anaphylaxis, exfoliative dermatitis, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome; neuromuscular blockade or resp paralysis.