24 Oct Vitamin D deficiency and CVD

AMI  risk is  COMPOUNDED by vitamin D deficiency

• Vitamin D deficiency  is involved in the development of atherosclerosis and coronary heart disease

• Low levels of 25(OH)D are associated with higher risk of myocardial infarction in a graded manner, even after controlling for factors known to be associated with coronary artery disease.

GiovannucciE  et al. Arch Int Med 2008; 168 (11): 1174-1180

Vitamin D + Atorvastatin FDC

Enhanced effectiveness of  Atorvastatin with optimum Vitamin D3 level

Castrillon JP, et al. International Journal of Endocrinology 2010

Indians: A unique population with vitamin D deficiency

70% of Indians today do have vitamin D deficiency

The higher risk of diabetes in Indians as compared to Caucasians  is partly explained by the facts such as

• persistent micronutrient abnormalities(YajnikCS,et al)

for the same BMI, Asians have a higher body fat percentage and  more central fat, a prominent abdominal obesity, a higher intramyocellular lipid and/or a higher liver fat content compared to Caucasians.( YajnikCS,et al; WulanSN,et al; McCarty MF.)

• have very poor vitamin D status, resulting in up-regulation of parathyroid hormone (PTH) resulting in the high risk for insulin resistance and associated pathologies

Benefits of vitamin D supplementation with statins

Vitamin D Supplement helps in

• Augmentation of CVD risk lowering by statin + Vitamin D
• Lowered risk of progression of atherosclerosis and CVD

Vitamin D Supplement Brands in India

Most of the recommended brands by the doctor:

• Dvion of Merck Limited
• Calcirol of Cadila Pharma
• Uprise D3 of Alkem

More known brands: