Dosage : Injection
Contains : Ceftriaxone sodium IP equivalent to Ceftriaxone
Category : Antibiotic
Uses : Bacterial infections
Price :

Xone contains Ceftriaxone which is a 3rd Generation Cephalosporin wide spectrum antibiotic. Xone It is available in 4 strengths, 125 mg, 250 mg, 500 mg and 1 gm.


Xone is used and administered in the treatment of both gram -ve and gram +ve bacterial infections.


Xone is used in the management of:

  • Meningitis
  • Intra-abdominal infections
  • Urinary tract infections
  • Uncomplicated Gonorrhea
  • Pelvic inflammatory disease
  • Skin and skin structure infections
  • Acute Undifferentiated Fever
  • Community-Acquired Pneumonia
  • Brain Abscess
  • Suppurative Intracranial Infections
  • Spinal Epidural Abscess


Xone is a brand from Alkem Laboratories, a leading Indian pharmaceutical company with global operations in more than 50 countries internationally. Alkem is engaged in the development, manufacture and sale of pharmaceutical and neutraceutical products.


Established in 1973, Alkem has a comprehensive portfolio of over 700 brands covering all the major therapeutic segments.Alkem has been been ranked the No.1 Anti-infective company in India for the past 10 years

Xone may have been recommended for you because you could be affected by bacterial infections. Bacterial infections include step throat, tuberculosis, gonorrhea, bacterial meningitis, pneumonia, upper respiratory tract infection, gastritis, food poisoning and eye infections.


Bacterial infections may be marked by localized redness, inflammation, pain or swelling. Common symptoms include inflammation, fatigue, vomiting, coughing and sneezing, fever, diarrhoea and cramping


Pathogenic bacteria can gain access into the body through a range of access routes. These include cuts, contaminated food or water, close contact with an infected person, physical contact with the faeces of an infected person, getting infected through another person’s coughing or sneezing or by touching contaminated surfaces like taps, toilet handles, nappies or toys.


A bacteria culture test can help find harmful bacteria in your body. A sample is taken from the patient’s blood, urine, skin or other part of the body during a bacteria culture test. The cells in the sample are put in a special environment in a lab to encourage cell growth. Depending on the type of bacteria, results are often available within a few days


As directed by your Physician


As directed by your Physician

Adverse Reactions/ Side Effects


Stevens-Johnson syndrome, toxic epidermal necrolysis (TEN)/Lyell’s syndrome, hypersensitivity, renal and gallbladder precipitation, pancreatitis secondary to biliary obstruction, renal lithiasis, superinfection.


Blood and lymphatic system disorders:

Eosinophilia, leucopenia, thrombocytopenia.


Gastrointestinal disorders:

Diarrhoea, oral candidiasis.


General disorders and administration site conditions:

Diaphoresis. Injury, poisoning and procedural complications: Pain, induration and tenderness at injection site (IM).



Increased hepatic enzymes, BUN and serum creatinine; sonographic abnormalities in the gallbladder.


Nervous system disorders:

Headache, dizziness.


Reproductive system and breast disorders:

Candidal vaginitis.


Skin and subcutaneous tissue disorders:



Vascular disorders:



Potentially Fatal:

Severe haemolytic anaemia, Clostridium difficile associated diarrhoea (CDAD).

Warnings and Precautions

Patient with history of allergy to penicillins or any drug, and history of gastrointestinal disease (e.g. colitis), renal lithiasis; hypercalciuria, impaired vit K synthesis or low vit K stores. Severe renal and hepatic impairment. Children. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, if affected, do not drive or operate machinery. Monitoring Parameters Monitor prothrombin time/INR. Monitor signs and symptoms of hypersensitivity.


Hypersensitivity to cephalosporins or history of severe hypersensitivity to other type of β-lactam antibiotic (e.g. penicillins, monobactams, carbapenems). Premature neonates up to a postmenstrual age of 41 weeks (gestational age and chronological age), full term neonates (up to 28 days of age) with hyperbilirubinaemia, jaundice, hypoalbuminaemia, or acidosis requiring IV Ca treatment, or Ca containing infusions.

Drug Interactions

May increase anticoagulant effect of vit K antagonists (e.g. warfarin). May increase nephrotoxicity of aminoglycosides. May diminish therapeutic effect of BCG, typhoid vaccine, Na picosulfate.


Potentially Fatal: Admin with Ca-containing IV solution may cause precipitation of a crystalline material in the lungs and kidneys.



Diarrhoea, nausea and vomiting.



Symptomatic treatment.



Store between 20-25°C. Protect from light.



Store between 20-25°C. Protect from light.

Mechanism of Action

Ceftriaxone is a 3rd generation cephalosporin antibiotic. It binds to 1 or more penicillin-binding proteins (PBPs) inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, leading to bacterial cell lysis and death.



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