Zedext is a combination medicine used in the treatment of dry cough. It relieves allergic symptoms such as sneezing, runny nose, watery eyes, and throat irritation. It also provides relief from congestion or stuffiness in the nose.
Zedex contains Dextromethorphan. Dextromethorphan (DXM or DM) is an antitussive drug. It is one of the active ingredients used to prevent coughs in many over-the-counter cold and cough medicines. Dextromethorphan has also found other uses in medicine, ranging from pain relief to psychological applications. It is sold in syrup, tablet, spray, and lozenge forms manufactured under several different brand names and generic labels.
Zedex is product from Wockhardt Limited. Wockhardt is a global pharmaceutical and biotechnology organisation, providing affordable, high-quality medicines for a healthier world. It is India’s leading research-based global healthcare enterprise with relevance in the fields of Pharmaceuticals, Biotechnology and a chain of advanced Super Speciality Hospitals.
Wockhardt is a true Indian Multi-National Company with a multi-ethnic workforce of 8600 Wockhardt Associates from 21 different nationalities globally. It has 3 research centres and 12 manufacturing plants, with businesses ranging from the manufacture and marketing of Pharmaceutical and Bio-pharmaceutical formulations, Active Pharmaceutical Ingredients (APIs) and Vaccines.
Cough is a reflex action that clears your airway of irritants and mucus. A nonproductive cough, also known as a dry cough, doesn’t produce phlegm or mucus. Many things — from allergies to acid reflux — can cause a dry cough. In some cases, there’s no obvious cause. Common causes are listed below-
Asthma is a condition in which your airways swell and become narrowed. Asthma-related coughs can be both productive and nonproductive, but they’re frequently nonproductive. Coughing is a common symptom of asthma, but it’s usually not the most prominent one. However, there’s a type of asthma called cough variant asthma (CVA) that includes a chronic dry cough as its main symptom.
Gastroesophageal reflux disease
Gastroesophageal reflux disease (GERD) is a type of chronic acid reflux. It happens when stomach acid regularly flows back up into your esophagus, which connects your mouth to your stomach. Stomach acid can irritate your esophagus and trigger your cough reflex.
Patient with history of drug abuse. Children. Treatment with a cough medicine in children (especially under 12 years old) should be considered carefully due to potential risks and limited evidence on efficacy. Pregnancy and lactation. Patient Counselling This drug can cause drowsiness or cognitive function impairment, if affected, do not drive or operate machinery.
Asthma, bronchitis, emphysema or other conditions where persistent or chronic cough occurs. Concomitant use or within 14 days of MAOI or SSRI therapy. Children <12 years.
Additive CNS effect when used with antihistamines, psychotropics and other CNS depressants. Increased toxic effect when used with potent CYP2D6 enzyme inhibitors (e.g. fluoxetine, paroxetine, quinidine, terbinafine).
Potentially Fatal: Increased risk of serotonin syndrome (e.g. hyperpyrexia, hallucinations, gross excitation or coma) when concomitantly used with MAOIs or SSRIs.
Supportive and symptomatic treatment. May perform gastric lavage. Naloxone may be effective in reversing toxicity.
Oral: Store between 20-25°C. Protect from light.
Mechanism of Action
Dextromethorphan, a centrally-acting antitussive agent, depresses the medullary cough centre through sigma receptor stimulation, resulting to decreased sensitivity of cough receptors and interruption of cough impulse transmission. Bromhexine is used in a condition where there is a lot of thick phlegm in the airways. As a mucolytic, it helps to relieve productive cough by thinning the phlegm in the airways and facilitating the removal of the mucus.