Zerodol P is a combination of Aceclofenac and Paracetamol.
Aceclofenac is a non-steroidal anti-inflammatory drug (NSAID) with marked anti-inflammatory and analgesic properties. It potently inhibits the synthesis of inflammatory mediators that cause pain, swelling, inflammation, and fever. In osteoarthritis and other such conditions, the loss of articular cartilage in the area causes joint pain, tenderness, stiffness, crepitus, and local inflammation. Aceclofenac has high permeability to penetrate into synovial joints thereby reducing the swelling and inflammation of joints.
Paracetamol is an analgesic and antipyretic medication used for mild-to-moderate pain and fever. Hence, Zerodol P is prescibed in conditions like osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis. It is also effective in other painful conditions such as dental and gynaecological conditions.
Zerodol P is brand from Ipca, a global pharmaceutical company. Ipca has been partnering healthcare globally in over 120 countries for more than 60 years and in markets as diverse as Africa, Asia, Australia, Europe and the US. It is a fully-integrated Indian pharmaceutical company manufacturing over 350 formulations. The formulations are produced right from the basic stage at manufacturing facilities inspected by the world’s most discerning drug regulatory authorities like US-FDA, UK-MHRA, EDQM-Europe, WHO-Geneva and many more.
Ipca is a therapy leader in India for anti-malarials and has leading brands in 5 therapeutic areas, with 3 of their branded formulations being ranked among the Top-300 Indian brands by ORG-IMS.
Prostaglandins are made at sites of injury or infection, where they cause inflammation, pain and fever as a part of the healing process. For example, when a blood vessel is injured or damaged, a prostaglandin called thromboxane is formed that stimulates clotting of the blood to prevent the further blood loss.
High levels of prostaglandins are produced in response to injury or infection and cause inflammation, which is associated with the symptoms of redness, swelling, pain and fever. However, this natural response sometimes lead to excess and chronic production of prostaglandins. Thus prostaglandins contribute to several diseases by causing unwanted inflammation. This unwanted inflammation leads to conditions like Arthritis, Tendinitis, Bursitis, Acute gout, Dysmenorrhoea, Migraine, Musculoskeletal pain, etc.
GI disease; renal or hepatic impairment; alcohol-dependent patients; asthma or allergic disorders; haemorrhagic disorders; hypertension; cardiac impairment. Elderly. Caution when driving or operating machinery. Monitor renal and hepatic function and blood counts during long term treatment. Persistently elevated hepatic enzyme levels may require drug withdrawal. Pregnancy, lactation.
Hypersensitivity. Moderate to severe renal or hepatic impairment; severe heart failure; pregnancy (third trimester).
Paracetamol: Reduced absorption of cholestyramine within 1 hr of administration. Accelerated absorption with metoclopramide. Aceclofenac: M0ay increase the plasma concentrations of lithium and digoxin. Increased nephrotoxicity with diuretics. Serum-potassium should be monitored when used with potassium-sparing diuretics. May enhance activity of anticoagulants. May increase plasma methotrexate levels leading to toxicity if administered within 2-4 hr of methotrexate admin. Risk of convulsions with quinolones.
Potentially Fatal: Paracetamol: Increased risk of liver damage in chronic alcoholics. Increased risk of toxicity with high doses or long term admin of barbiturates, carbamazepine, hydantoins, isoniazid, rifampin and sulfinpyrazone.
Empty stomach promptly by gastric lavage or induction of emesis. Administer standard supportive measures.
Mechanism of Action
Aceclofenac is a phenylacetic acid derivative that inhibits synthesis of the inflammatory cytokines interleukin-1b and tumour necrosis factor, and inhibits prostaglandin E2 production. It increases glycosaminoglycans (GAG) synthesis, the principal macromolecule of the extracellular matrix, which aids in repair and regeneration of articular cartilage. Thus, aceclofenac has +ve effects on cartilage anabolism combined with modulating effect of matrix catabolism. Paracetamol has analgesic and antipyretic action with weak anti-inflammatory activity. It produces analgesia by increasing pain threshold and antipyresis by acting on the hypothalamic heat-regulating centre.