Dosage : Tablet
Contains : Ranitidine
Category : Antacid
Uses : Hyperacidity, Gerd, Erosive Gastritis, Zollinger Edison Syndrome
Price :

Zinetac  is a medicine which helps stop hyperacidity . It is a blocker of  histamine receptors that are present on the stomach cell that mediate gastric secretion (H2 receptors). It is a competitive and reversible inhibitor of histamine H2 receptors on the parietal cells in the stomach, thereby decreasing the normal and meal stimulated secretion of stomach acids. In addition the substances that promote acid secretion also have a reduced effect on the parietal cells when H2 receptors are blocked .Zinetac is used in the treatment of duodenal ulcers, gastric ulcers, GERD, erosive gastritis, Zollinger Ellison Syndrome and hypersecretory conditions.


Zinetac is manufactured by Glaxosmithline .GlaxoSmithkline is the world’s leading research based pharmaceutical, healthcare and vaccine company. The company is committed to improve the quality of human life by enabling people to do more, feel better and live longer.

You may have been prescribed Zinetac as you may be suffering from either Hyperacidity or GERD or Erosive gastritis  or Zollinger Edison syndrome.


Hyperacidity is a condition wherein there is abnormally high acid secretion in the stomach cavity which causes heart burn as  well as heavy burping post meal intake .Recurrent acidity can lead to loss of the stomach mucus ( protective ) layer and can cause peptic ulcers ( stomach ulcer).


GERD is nothing but gastric oesophageal reflux disease wherein the stomach acid flows upwards in the oesophagus which is caused due to defective oesophageal sphincter ( valve ) that is present between stomach and oesophagus .This leads to heartburn as major symptom and makes swallowing any food difficult for the patient.


Erosive gastritis is precursor to peptic ulcer .The constantly high volume of acid leads to erosion of the gastric epithelium which cause the stomach cavity to be inflamed and is usually the first step in peptic ulcer. This is usually associated with pain on eating any meal.


Zollinger Edison syndrome is a genetic disorder wherein the islet cells in the gastric region grow abnormally and produce huge quantum of acid. Persistent high acid production also leads to peptic ulcers.


As directed by your Physician


As directed by your Physician

Adverse Reactions/ Side Effects

Blood and lymphatic system disorders: Cardiac disorders: Dyspnoea, rarely, asystole, atrioventricular block, bradycardia (rapid IV administration), tachycardia, ventricular premature contractions.


Gastrointestinal disorders: Abdominal pain, constipation, nausea, abdominal distress, diarrhoea, vomiting.


General disorders and administration site conditions: Immune system disorders: Hypersensitivity reactions (e.g. fever, rash, bronchospasm, eosinophilia), anaphylaxis, angioneurotic oedema). Infections and infestations: Pneumonia. Injury, poisoning and procedural complications: Pain, burning sensation, pruritus at injection site (IV/IM inj).


Metabolism and nutrition disorders: Rarely, acute porphyria. Musculoskeletal and connective tissue disorders: Rarely, arthralgia, myalgia. Nervous system disorders: Headache (sometimes severe)


Warnings and Precautions

Patient with chronic lung disease, diabetes, factors predisposing to cardiac rhythm disturbances. Immunocompromised or severely ill patient. Rule out gastric malignancy or possibility of malignancy prior to initiation of therapy. Renal and hepatic impairment. Children. Pregnancy and lactation. Patient Counselling This drug may cause dizziness, drowsiness or blurred vision, if affected, do not drive or operate machinery. Monitoring Parameters Monitor liver and kidney (e.g. serum creatinine) functions, occult blood with gastrointestinal bleeding, and signs of confusion.


History of acute porphyria.

Drug Interactions

Altered prothrombin time and increased serum concentration with coumarin anticoagulants (e.g. warfarin). May reduce the excretion and increase plasma concentrations of procainamide and N-acetylprocainamide (high dose ranitidine). May alter the absorption of pH-dependent drugs which may result in either an increase in absorption (e.g. triazolam, glipizide, midazolam) or decrease in absorption (e.g. atazanavir, gefitnib, ketoconazole, delaviridine). Decreased absorption with co-administration of high dose sucralfate.


Symptoms: Transient adverse effects similar to those experienced with normal doses, additionally, abnormalities of gait and hypotension. Management: Symptomatic and supportive treatment with removal of unabsorbed drugs from the gastrointestinal tract.



Store below 25°C. Protect from light and moisture.



Store below 25°C. Protect from light and moisture.



Store below 25°C. Protect from light and moisture.

Mechanism of Action

Ranitidine competitively and reversibly inhibits histamine at H2-receptors of the gastric parietal cells thereby inhibiting gastric acid secretion, gastric volume and reducing hydrogen ion concentration.






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